Single cell OMICS technologies

  • University of Luxembourg
  • From Luxembourg
  • Responsive
  • Innovative Products and Technologies

Summary of the technology

The Integrative Cell Signalling group at the LCSB investigates changes of cellular heterogeneity in health and disease at single cell resolution. In diverse projects including cell differentiation, cancer heterogeneity and brain chraracterization, we develop and apply single cell RNA sequencing (sc-RNAseq) methods such as Drop-seq, CITE-seq, ATAC-seq, Fluidigm C1, InDrop or SPLiT-seq.

University of Luxembourg

Details of the Technology Offer

The recent technology of single cell transcriptomics and epigenomics allows for in depth characterization of cellular states. Investigating tissue heterogeneity at single cell resolution gives new insights into underlying disease mechanisms and is able to identify driving cellular subpopulations . Combining scRNA-seq technology with membrane-associated protein tagging (CITE-seq) can give additional layer of information in understanding mRNA-protein relationship on a temporal scale. In addition, single cell chromatin accessibility technology (ATAC-seq) allows for identification and profiling of distinct regulatory modules across different cell types within heterogeneous samples. At the LCSB, we provide access to these techniques by customized and commercial pipelines and develop targeted bioinformatics analysis methods to integrate the high-dimensional data.


  1. Inexpensive capturing of whole cell transcriptome on a single cell level (Drop-seq).
  • Possibility to link scRNA-seq data to 11 or more barcoded protein antibodies (CITE-seq)
  1. 10x Genomics can offer even higher transcriptome capturing ratio, which makes it a great tool for investigating nuclei or cells with low transcript abundance (snRNAseq or ATAC-seq)
  • With in-house developed analyses pipeline together with some of the leading software available ICS can offer expertise and support dealing with this type of high dimensional data.
  • We have applied scRNA-seq methods in wide range of project from cancer metastasis, immunological responses up to neurodegeneration.

Related Keywords

  • Genome Research
  • Cellular and Molecular Biology Technology
  • Gene - DNA Therapy
  • Medicine, Human Health
  • Biological Sciences
  • E-Health
  • Biology / Biotechnology
  • Health information management
  • Medical Health related
  • Recombinant DNA
  • Applications software

About University of Luxembourg

The University of Luxembourg, founded in 2003, is multilingual, international and strongly focused on research. Its students and staff have chosen a modern institution with a personal atmosphere, close to the European institutions, international companies and the financial place.

Teaching, research and knowledge transfer at the highest international level: those are the goals that this university set from the start. With 270 professors, associate professors, assistant professors and senior lecturers, students from 130 different countries and lecturers originating from 20 different countries, the University offers a multicultural environment. Exchange agreements and research cooperations exist with 354 universities around the world.

About 6,783 students (Bachelor, Master, PhD/Doctorate, learning courses, vocational training and lifelong learning) can choose from over 60 degrees, offered by:
- The Faculty of Science, Technology and Medicine,
- The Faculty of Law, Economics and Finance,
- The Faculty of Humanities, Education and Social Sciences.

The central research priorities of the University of Luxembourg are:
- Materials Science
- Computer Science & ICT Security
- European and International Law
- Finance and Financial Innovation
- Education
- Digital and Contemporary History

as well as cross-disciplinary themes (details at
- Health and Systems Biomedicine
- Data Modelling and Simulation (formerly known as Computational Sciences)

University Rankings
- Among the top 250 universities in the Times Higher Education (THE) World University Rankings 2021.
- No. 3 worldwide in the THE “international outlook” Rankings 2021.
- No. 20 worldwide in the THE Young University Rankings 2021.

University of Luxembourg

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