The CLEAVE-seq technology enables increased sensitivity, speed, scale and cost effectiveness in the detection of DNA double strand breaks induced by DNA endonucleases.
PURPOSE
Determination of on- and offtargets for DNA endonucleases (e.g. CRISPR-Cas9).
Selection of the most specific Cas9-gRNA candidate for in vitro, ex vivo and in vivo genome editing.
FIELDS OF APPLICATION
Genome editing; gene therapy; genetic engineering in plant or animal systems for industrial application; tools for fundamental research.
INVENTORS
•Stephane DESCHAMPS
•Virginijus SIKSNYS
•Joshua K. YOUNG
•Mindaugas ZAREMBA
RELEVANT PUBLICATIONS
Young et al. (2019)Scientific Reports,doi: 10.1038/s41598-019-43141-6.
Current development status
Laboratory prototypes
Vilnius University is the largest Lithuanian higher education and research institution. We are open for collaborative research, contract research or any cooperation activities with partners from business and public organizations. Multidisciplinary approach on R&D activities at Vilnius University provides unique opportunity to incorporate methodologies, perspectives, data and concepts from all scientific fields – biomedical, physical sciences, technologies, social sciences and humanities. We believe that the right mix of shared intentions with our partners and clients, outstanding teams of university researchers and open access to modern R&D infrastructure deliver remarkable solutions that can change organizations, markets and society in general.
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