Colorimetric sensors for the detection and quantification of amino acids, peptides and proteins applied to monitoring chronic wounds

  • From Spain
  • Responsive
  • Patents for licensing

Summary of the technology

The invention provides new crosslinked copolymers derived from ninhydirin, and their use, in film, membrane or gel form, as chromogenic sensors in the presence of amino acids, small proteins or peptides present in aqueous samples, wounds, wound exudates, biological samples and medical samples.

The capable of colour change of the new sensors in the presence of healing parameters allows monitoring the evolution of chronic wounds using RGB parameters of a digital photograph, anticipating the diagnosis and treatment of patients.


New and innovative aspects

The difficulties of healing of skin wounds is a problem of the first magnitude that affects approximately 1-2% of the population and the great harm to patients, while it represents an enormous economic cost.

The healing process is complex, and the diagnosis and treatment of chronic wounds is challenging. Medical staff perform these evaluations through visual inspections to establish treatments that can last for long periods of time.

This monitoring technology based on the quantitative detection of healing parameters is a great advance in the realization of preventive diagnoses, control of infections in real time, reduction of the additional response time of the sanitary economic cost.

Main advantages of its use

The main advantage is the ability to detect healing markers such as protease, amino acids, small proteins or peptides present in aqueous and/or biological media, by means of a simple color change quickly, without prior manipulation, and without interference.


The synthesis of the structure (I) derived from ninhydrin within the polymeric material itself, by means of direct modification in the polymer chains, allows obtaining a stable material for years without any type of storage or special treatment.


This development allows the detection, quantification and monitoring of chronic wounds by using the RGB parameters of a digital photograph. The chronic wound monitoring device can reduce the number of infections of patients, decrease prolonged hospitalizations, to follow the evolution of the patients after being discharged from hospital and reduce laboratory tests associated with the diagnosis of chronic wounds.

Intellectual property status

Protected by Patent P202030077

Current development status

The technology related to the synthesis method is developed.

Desired business relationship

Commercial agreement; License agreement; Technical cooperation: further development; Technical cooperation: testing new applications; Technical cooperation: adaptation to specific needs.

Intellectual property status

Attached documents

Related Keywords

  • Biological Sciences
  • Measurements and Standards
  • Measurement Tools
  • Analyses / Test Facilities and Methods
  • Applications for Health
  • Medicine, Human Health
  • Health information management
  • Detection and Analysis methods
  • Electronics Related Market
  • Genetic Engineering / Molecular Biology
  • Medical Health related
  • Industrial Products
  • Other
  • Medical/health
  • Monitoring equipment
  • Proteins
  • aminoacids
  • peptides
  • protease
  • scarring
  • colorimetric sensors
  • monitoring of chronic wounds
  • venous ulcers
  • dermathology
  • skin
  • chronic wounds


The aim of the The Technology Transfer Office (TTO) of the Univesidad de Burgos is to promote Innovation technology through the reseach results transfer and the conexions between the University and the new needs and requirements of the society - we are the link between the University and the Industry. Contact person: José Manuel López (


Never miss an update from UNIVERSIDAD DE BURGOS

Create your free account to connect with UNIVERSIDAD DE BURGOS and thousands of other innovative organizations and professionals worldwide


Send a request for information

About Technology Offers

Technology Offers on Innoget are directly posted
and managed by its members as well as evaluation of requests for information. Innoget is the trusted open innovation and science network aimed at directly connect industry needs with professionals online.


Need help requesting additional information or have questions regarding this Technology Offer?
Contact Innoget support