New dendrimer as a contrast agent in magnetic resonance imaging (MRI)

Posted by Alfonso from ICMAB-CSICResponsive · Patents for licensing · Spain

Summary of the technology

ICMAB has developed a new dendrimer that can be used as a contrast agent (CA) in magnetic resonance imaging (MRI). This new CA is non-toxic and it is expelled from live tissues in hours, making it the best option when periodical MRI tests are needed.


Description of the technology

has developed a new contrast agent (CA) for magnetic resonance imaging (MRI). The inventors have expertise in developing new dendrimers for biological applications.

MRI is a well-known imaging technique for non-invasive medical diagnosis and follow-up. CA provides images of different tissues, tumours and related pathological conditions of the same tissue in excellent detail due to their enhanced different brightness.

The most widely used CAs are based on metal ions like gadolinium (Gd III). Gd can be considered as a toxic metal, it accumulates in some tissues (brain, bones, kidneys, etc.) and there is a relation between Gd administration and the development of nephrogenic systemic fibrosis.

The new CA is a dendrimer with proxyl radicals. It is a Gd free non-toxic molecule with high solubility in biological fluids, long term contrast activity and it is expelled in hours from live tissues without accumulating in any of them.

The characterístics of the new CA make it the ideal option when repeated MRI tests are needed.

The advantatges of the technology are:

- Metal free non-toxic CA based on a dendrimer with proxyl radicals.

- Non accumulation of CA in tissues, fastly expelled and easily degradated.

- Same contrast as Gd based CAs with 4 times less concentration.

-Allows repeated imaging studies without health negative effects.

Current development status

Laboratory prototypes


Magnetic Resonance Imaging Contrast Agent

Desired business relationship

Patent licensing

Technology development

Intellectual property status

Patent already applied for

Technology Owner


Research Institute

Related keywords

  • Electronics, IT and Telecomms
  • Electronics, Microelectronics
  • Biological Sciences
  • Medicine, Human Health
  • Diagnostics, Diagnosis
  • Biology / Biotechnology
  • Micro- and Nanotechnology related to Biological sciences
  • Imaging, Image Processing, Pattern Recognition
  • Medical Health related
  • Diagnostic
  • magnetic resonance imaging (mri)
  • dendrimer
  • contrast agent
  • magnetic resonance
  • mri


Research Institute from Spain

Spanish Research Institute focused on the development of new materials

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