Summary of the technology
PolymP®-Active (Zn) is a breakthrough material that we have just patented for potentially treating dentin hypersensitivity. This new material (based on biocompatible polymeric particles) shows, among many others, the following key benefits:
-Induces natural remineralization in few hours enhancing the precipitation of natural minerals that are not dissolved by saliva.
-Low Mohs hardness: Do not result in dentin or enamel abrasion.
-Fully occludes dentinal tubules enhancing surface nanohardness.
-Possess antibacterial activity.
-Inhibits dentin metalloproteinases, preventing the accelerated destruction of dentin.
From a regulatory standpoint, the product could be developed as a cosmetic.
Description of the technology
Dentin hypersensitivity (DH) is a sharp and short duration dental pain, arising from exposed dentin surfaces in response to different type of stimuli such as thermal, evaporative, tactile, osmotic, chemical or electrical. Overall, DH is estimated to affect to some degree more than 20% of the general population. It is a feed-forward process characterized by the loss of the enamel and dentin due to dental demineralization by acid foods, cariogenic bacteria and the activation of dentine Matrix Metalloproteinases (MMPs) that follows dental demineralization. The opening of dentinal tubules allows the movement of internal fluids and results in pain.
PolymP®-Active (Zn)are Zinc functionalized polymer spherical particles with size ranging between 200 nm and 250 nm. From a regulatory standpoint, the product could be developed as a Cosmetic. The particles have as main features:
- Highly bioactive and contribute to fast dentin remineralization by enhancing the precipitation of natural minerals that are not dissolved by saliva.
- Occlude dentin tubules in a very efficient way.
- Increase dentin mechanical properties, then dentin will become resistant to subsequent abrasion.
- Possess antibacterial activity.
- Inhibit dentin metalloproteinases, preventing the accelerated destruction of dentin.
- Low Mohs hardness: Do not result in dentin or enamel abrasion.
Topical application of these particles is expected to reduce dentin hypersensitivity. Major expected advantages versus main competitor (Sensodyne (GSK) based on Novamin Technology) are the irreversible filling of dentine tubules and the lack of abrasion.
These particles and their potential therapeutic applications are protected by a recent patent application. Taking into account the prevalence of dental hypersensitivity we consider that there are very large market opportunities for our agent. In 2015 the sensitivity toothpaste market was worth €900 million.
Our objective is to complete the development of this agent in order to move to the market. To this end we are preparing a development plan, including the regulatory studies. We can carry out these studies in collaboration with a partner specialized in dental care or by ourselves if we obtain financial support.
We are open to discuss in licensing/investment terms.
Intellectual property status
Patent already applied for
Additional information (attached documents)