Histone H3-K9 Methylation Assay Kit

  • Creative BioMart
  • From United States
  • Responsive
  • Innovative Products and Technologies

Summary of the technology

Histone H3-K9 Methylation Assay Kit is use for measuring methylation of histone H3-K9.
For specifically measuring histone H3-K9 methylation using a variety of mammalian cells including fresh and frozen tissues, cultured adherent and suspension cells.

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Details of the Technology Offer

Epigenetic activation or inactivation of genes plays a critical role in many important human diseases, especially in cancer. A major mechanism for epigenetic inactivation of the genes is methylation of CpG islands in genome DNA caused by DNA methyltransferases. Histone methyltransferases (HMTs) control or regulate DNA methylation through chromatin-dependent transcription repression or activation. HMTs transfer 1-3 methyl groups from S-adenosyl-L-methionine to the lysine and arginine residues of histone proteins. ESET, G9a, SUV39-h1, SUV39- h2, SETDB1, Dim-5 and Eu-HMTase are histone methyltransferases that catalyze methylation of histone H3 at lysine 9 (H3-K9) in mammalian cells. H3-K9 methylation mediates heterochromatin formation by forming a binding site for HP1 and also participates in silencing gene expression at euchromatic sites. Increased H3-K9 methylation is also found to be involved in some pathological processes such as cancer progress. There are only a couple of methods such as western blot used for measuring histone H3-K9 methylation. These methods available so far are time consuming and labor intensive, or have low throughput. The Histone H3-K9 Methylation Assay Kit addresses theses problems by using a unique procedure to measure methylation of histone H3-K9.


Related Keywords

  • Biological Sciences
  • Biology / Biotechnology
  • Genetic Engineering / Molecular Biology
  • Gene Expression, Proteom Research Market
  • Enzymology/Protein Engineering/Fermentation

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