RAMOT at Tel Aviv University Ltd.

Novel ALS biomarkers:Towards diagnostics and potential therapy

Posted by RAMOT at Tel Aviv University Ltd.Responsive · Innovative Products and Technologies · Israel

Summary of the technology

We have identified ALS-specific biomarker candidate genes that are differentially expressed in blood and bone marrow samples from ALS patients. These biomarkers can be used for ALS diagnosis. Most importantly, these biomarkers can be used as targets for screening and identifying lead compounds for the treatment of ALS.
Project ID : 10-2009-82

The Technology
Novel ALS biomarkers, differentially expressed in blood and bone marrow samples from ALS patients have been identified. These are Cytoplasmic FMR Interacting Protein 2 (CyFIP2) and Retinoblastoma (Rb) Binding Protein 9 (RbBP9). Both demonstrate significant decrease in post transcriptional RNA editing and significant difference in gene expression in peripheral blood lymphocytes isolated from blood samples (17 ALS patients), as seen by quantitative real time-PCR (qRT-PCR) and western blot suggesting a problem in the regulation of these genes in ALS.

CyFIP2 & RbBP9 are associated with cellular stress, cell death and repair. Therefore, these biomarkers can be used for ALS diagnosis and as targets for screening and identifying lead compounds for the treatment of ALS.

Data-to-date
Differential expression of these genes was tested in peripheral blood leukocytes isolated from blood samples of 17 ALS patients. It was discovered that expression levels of CyFIP2 and RbBP9 were significantly different compared to the levels of expression of these two genes as compared with 19 normal PBL samples.

Patent status
WO2011/030336

Publication

Dis Markers. 2012; 32(4):211-20

Project manager

Elisha Natan
Director BD

Project researchers

Miguel Enrique Weil
T.A.U Tel Aviv University, Life Sciences
Cell Research and Immunology

Related keywords

  • Medicine, Human Health
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  • Stem cells and biobanks
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  • Diagnostic
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  • Pharmaceutical Indications
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About RAMOT at Tel Aviv University Ltd.

Technology Transfer Office from Israel

Ramot is Tel Aviv University's (TAU) technology transfer company and its liaison to industry, bringing promising scientific discoveries made at

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