RAMOT at Tel Aviv University Ltd.

Novel oral formulation of Insulin

Posted by RAMOT at Tel Aviv University Ltd.Responsive · Innovative Products and Technologies · Israel

Summary of the technology

Gagomers are novel particles (neither liposomes nor microspheres/ nanospheres) composed of hyaluronan shell which is crossed linked to phospholipids and can be generated either as micro or nano particles. The research team at Tel Aviv University has demonstrated that: (1) Gagomers efficiently encapsulate fibrillar Insulin (2) gagomers are protecting the insulin in the GIT (3) Due to the hyaluronan shell Gagomers are targeting the Insulin to intestinal mucosa and show muco-adhesive properties in the intestine and (4) In vivo studies with diabetic (STZ-induced) mice, under conditions that mimic human eating habits, demonstrated an anti-Glycemic effect reducing blood glucose levels from diabetic to normal.


Project ID : 10-2008-113

The Technology
Gagomers are novel particles (neither liposomes nor microspheres/ nanospheres) composed of hyaluronan shell which is crossed linked to phospholipids and can be generated either as micro or nano particles. The research team at Tel Aviv University has demonstrated that: (1) Gagomers efficiently encapsulate fibrillar Insulin (2) gagomers are protecting the insulin in the GIT (3) Due to the hyaluronan shell Gagomers are targeting the Insulin to intestinal mucosa and show muco-adhesive properties in the intestine and (4) In vivo studies with diabetic (STZ-induced) mice, under conditions that mimic human eating habits, demonstrated an anti-Glycemic effect reducing blood glucose levels from diabetic to normal.

Potential Application
Oral delivery of mid to long-acting Insulin

Stage of Development

  • Extensive in vitro studies on Gagomers production and fibrillar insulin encapsulation
  • In vivo proof of concept in STZ mice
  • Preliminary Safety data

Patents
PCT patent application (WO 2009/108554 A2)

Supporting Publications
Dekel Y, Glucksam Y and Margalit R, Novel fibrillar insulin formulations for oral administration: Formulation and in vivo studies in diabetic mice. Journal of Controlled Release 2012, 143: 128–135.


Project manager

Adi Elkeles
BD Manager

Project researchers

Rimona Margalit
T.A.U Tel Aviv University, Life Sciences
The Department of Biochemistry and Molecular Biology

Yaron Dekel
T.A.U Tel Aviv University, Life Sciences
The Department of Biochemistry and Molecular Biology

Related keywords

  • Medicine, Human Health
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  • Stem cells and biobanks
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  • Therapeutic
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About RAMOT at Tel Aviv University Ltd.

Technology Transfer Office from Israel

Ramot is Tel Aviv University's (TAU) technology transfer company and its liaison to industry, bringing promising scientific discoveries made at

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