Summary of the technology
The device has the following advantages over existing equipment:
Allows quantitative extraction efficiency, solving one of the main drawbacks of IT-SPME systems
Broadens applicability of IT-SPME thus making available its advantages (automation, precision) to specific analyses that require high sensitivity of analytes estimation.
Description of the tech for sale
In-tube solid phase microextraction (IT-SPME) is a well known sample preparation technique for its coupling with analytical instruments such as capillary liquid chromatography. In this technique, extraction, desorption and injection can be performed automatically, shortening the analysis time and improving precision. Notwithstanding, IT-SPME has revealed disadvantages such as the low extraction efficiency (10%-30%) due to large breakthrough volume and small amount of adsorbent phases. Researchers from Universitat de València have designed a new IT-SPME on the basis of magnetic microfluidic principles improving extraction efficiency of conventional IT-SPME systems. The new system called Magnetic-IT-SPME allows quantitative extraction efficiency using magnetic hybrid materials as adsorbent phase into capillary columns and applying external magnetic fields.
The device uses a hybrid material (SiO2 supported Fe3O4 magnetic nanoparticles) immobilized in the internal surface of a bared fused silica capillary column to obtain a magnetic adsorbent extraction phase. The capillary column is placed inside a magnetic coil that allows the application of variable magnetic field. The application of a controlled magnetic field results in quantitative extraction efficiencies of the target analytes. The new device has been successfully validated with several target analytes like acetylsalicylic acid, acetaminophen, atenolol, diclofenac and ibuprofen.
Main advantages of its use
- The new system called Magnetic-IT-SPME allows quantitative extraction efficiency using magnetic hybrid materials as adsorbent phase and applying external magnetic fields.
- This analytical instrument is useful for all those sectors that require high sensitivity of analyte quantification, particularly for organic compounds. For example:• Environmental industry• Pharmaceutical industry• Food industry• Biochemistry• Medical chemistry• Industrial chemistry