Universitat de València

Magnetic In-Tube Solid Phase Microextraction

Posted by Universitat de ValènciaResponsive · Innovative Products and Technologies · Spain

Summary of the technology

The device has the following advantages over existing equipment:
 Allows quantitative extraction efficiency, solving one of the main drawbacks of IT-SPME systems
 Broadens applicability of IT-SPME thus making available its advantages (automation, precision) to specific analyses that require high sensitivity of analytes estimation.

Description of the tech for sale

In-tube solid phase microextraction (IT-SPME) is a well known sample preparation technique for its coupling with analytical instruments such as capillary liquid chromatography. In this technique, extraction, desorption and injection can be performed automatically, shortening the analysis time and improving precision. Notwithstanding, IT-SPME has revealed disadvantages such as the low extraction efficiency (10%-30%) due to large breakthrough volume and small amount of adsorbent phases. Researchers from Universitat de València have designed a new IT-SPME on the basis of magnetic microfluidic principles improving extraction efficiency of conventional IT-SPME systems. The new system called Magnetic-IT-SPME allows quantitative extraction efficiency using magnetic hybrid materials as adsorbent phase into capillary columns and applying external magnetic fields.


The device uses a hybrid material (SiO2 supported Fe3O4 magnetic nanoparticles) immobilized in the internal surface of a bared fused silica capillary column to obtain a magnetic adsorbent extraction phase. The capillary column is placed inside a magnetic coil that allows the application of variable magnetic field. The application of a controlled magnetic field results in quantitative extraction efficiencies of the target analytes. The new device has been successfully validated with several target analytes like acetylsalicylic acid, acetaminophen, atenolol, diclofenac and ibuprofen.

Main advantages of its use

  • The new system called Magnetic-IT-SPME allows quantitative extraction efficiency using magnetic hybrid materials as adsorbent phase and applying external magnetic fields.


  • This analytical instrument is useful for all those sectors that require high sensitivity of analyte quantification, particularly for organic compounds. For example:• Environmental industry• Pharmaceutical industry• Food industry• Biochemistry• Medical chemistry• Industrial chemistry

Related keywords

  • Biological Sciences
  • Industrial Technologies
  • Physical Sciences and Exact Sciences
  • Protecting Man and Environment
  • Agrofood Industry
  • Materials Technology
  • Solid biomass
  • Chemistry
  • Extraction
  • Genetic Engineering / Molecular Biology
  • Industrial Products
  • Consumer related
  • Medical Health related
  • Analytical instrument
  • analytical chemistry
  • materials technology
  • Test Facilities and Methods
  • Scientific instrumentation
  • analytes
  • organic compounds.

About Universitat de València

Public Agency from Spain

The University of Valencia, founded over five centuries ago by the Juries of Valencia, is a modern European public University, open to almost all branches of knowledge: social, economic and legal sciences, Basic experimental sciences, engineering and Tehcniques, health sciences, educational sciences and the humanities.
More than 41,000 undergraduate students, 4,000 postgraduate students, 2,000 students from other universities all over the world, take classes taught by more than 4,000 professors, lectures and researchers at our campuses (more than 440.000 square meters) with the support of over 1,700 administration and service staff.
Our university community is committed to being a university of reference: we are ranked 4º in Europe in receiving Erasmus students and 5ª in sending of students (Ranking Erasmus Mobility); It is fourth spanish university in research at the international level, ranking between 201 and 300, according to Shanghai Jiao Tong University Rankings.
The University of Valencia is working in a wide range of investigative fields. The results of this activity are applied in a variety of productive sectors and social areas. Information of interest for businesses and public bodies about the Scientific and Technological Capacity of the University of Valencia is made available and offered for socioeconomic transfer through its Research Results Transfer Office (OTRI).
The OTRI is a service that manages and assesses in the generation and transfer of University knowledge towards the industry, encouraging the University role as an active agent in the economic and social development; makes easier the access to the University of Valencia research facilities; manage the intellectual property of the research results produced in the University and carry out its valorisation for efficient transfer, and offers orientation of university research groups towards the needs of Business, promoting and guiding effective relationships for exchange of knowledge applied to the needs of social and industrial environment, making easier its information dissemination and transfer.

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