UATEC - Unidade de Transferência de Tecnologia

New Bioreactor for tissue engineering

Posted by UATEC - Unidade de Transferência de TecnologiaResponsive · Innovative Products and Technologies · Portugal

Summary of the technology

When compared to other solutions, this system as the following advantages:
It allows to establish a correlation between a multiplicity of mechanical properties and also biochemical properties
•It is highly flexible in the sense that it can be used with different cell types
•It can be used using different cell culture devices
•It may present up to 3 simultaneous movements with only one actuator
•It has a specific software that allows the control the diferent mechanical parameters
•It allows for comparison of static and dynamic cultures
•It allows the combination of several diferente experimente set-ups
•It allows the adaptation of type and mode of mechanical stimuli in relation to the other bioreactor parameters or in fucntion of the biochemical and biomechanical characteristics of the 2D or 3D construct in real time which allows an improvement of its properties

Description of the technology

A group of researchers from a Portuguese University has developed a new bioreactor for tissue engineering. The proposed device allows not only for cell growth but also a deep biochemical and biomechanical characterization of both two-dimensional and tree-dimensional constructs and in real time, without interrupting the cellular growth. The modes and types of stimulation are modified independently by the bioreactor according to the biomechanical and biochemical properties of cellular structures by one or more objective functions previously defined in the control system. The university is looking for industrial partners interested for joint development and/or licensing agreement for production and commercialization of the device

Specifications

The invention relates to a bioreactor able to carry out the biomechanical and biochemical characterization of two-dimensional and three-dimensional cell constructs for tissue engineering in real time without interruption of cell growth, allowing for a correlation between the mechanical properties including the modulus of elasticity compression / tension, shear modulus of rigidity, modulus and flexural strength, and biochemical properties including permeability, pH and oxygen tension, and the different systems and modes of mechanical stimulation and / or electrical stimulation and / or magnetic stimulation, including compression / axial traction, cut by twisting, bending, perfusion and hydrostatic compression, the cell construction that is submitted in order to develop a fully functional artificial tissue for implantation in vivo. The modes and types of stimulation are modified independently by the bioreactor according to the biomechanical and biochemical properties of cellular structures by one or more objective functions previously defined in the control system

Main advantages of its use

  • allows for comparison of static and dynamic cultures
  • allows the adaptation of type and mode of mechanical stimuli in relation to the other bioreactor parameters or in function of the biochemical and biomechanical characteristics of the 2D or 3D construct in real time which allows an improvement of its properties
  • allows the combination of several differente experiment set-ups
  • different cell culture devices can be used
  • has a specific software coupled that allows the control the different mechanical parameters
  • highly flexible in the sense that it can be used with different cell types
  • up to 3 simultaneous movements with only one actuator are allowed

Applications

  • This technology has applications on the bioengineering domain, namely in tissue engineering. It may be of interest to Electromechanical manufacturers , Laboratory equipment manufacturers, Tissue engineering companies as well as to R&D institutions.

Related keywords

  • Biological Sciences
  • Cellular and Molecular Biology Market
  • Biochemistry / Biophysics Market
  • tissue engineering
  • Bioengineering
  • tissues
  • cellular structures
  • cell culture devices
  • bioreactor
  • laboratory equipment

About UATEC - Unidade de Transferência de Tecnologia

Technology Transfer Office from Portugal

The University of Aveiro is a young and innovative university, which fosters entrepreneurship and technology and knowledge transfer, with expertise in a wide range of knowledge areas namely IT, Life Sciences (Biology, Chemistry, Biochemistry, Health, Environmental Sciences), Nanotechnology and Materials Science, Mechanics, Physics, Mathematics, Building, Design and Management. UATEC is the Technology Transfer Office of University of Aveiro. This office engages in value adding activities such as start-up and spin-off creation, support to university-industry cooperation, (sponsored research and consultancy services) IP protection and prosecution, licensing, marketing, among others. It covers four main interrelated functional areas – Intellectual Property Management, Licensing, Entrepreneurship, and Industry Liaison.

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