This technology provides a novel anti-aging approach by correcting cellular senescence through metabolic rebalancing rather than cell elimination.
An ENO1-targeting oxazole analogue restores mitochondrial-centered energy metabolism and reduces glycolytic dependence in senescent cells.
This state-level intervention attenuates key senescence phenotypes and supports functional rejuvenation.
The platform offers a differentiated alternative to senolytic strategies with broad applicability across nutraceutical, cosmetic, and pharmaceutical development.
Cellular senescence is increasingly recognized as a dysregulated metabolic state characterized by excessive glycolysis, impaired mitochondrial function, and self-reinforcing oxidative stress. This technology targets ENO1-mediated glycolytic flow to correct this imbalance at the state level.
The lead oxazole analogue, KB2764, restores the balance between glycolysis and mitochondrial respiration, resulting in improved mitochondrial membrane potential, reduced ROS levels, stabilized telomere length, and attenuation of senescence-associated phenotypes. These effects have been validated in cellular models and further supported by lifespan and healthspan improvements in Caenorhabditis elegans.
By focusing on metabolic normalization rather than senescent cell removal, the platform enables a differentiated safety and efficacy profile. It supports compound library expansion, preclinical development, and biomarker-based efficacy standardization, with commercialization opportunities through IP licensing and collaborative R&D in anti-aging, metabolic health, and mitochondrial dysfunction-related applications.
IBU Inc. is a technology commercialization and consulting firm supporting licensing, co-development, and venture creation based on deep-tech and research-originated technologies.
The company operates as a technology transfer partner, startup studio, and accelerator, working with universities, research institutes, and industry players.
IBU Inc. connects technology owners with corporate partners and investors by structuring collaboration models, commercialization strategies, and market-oriented pathways.
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