Novel glucose-lowering small molecules.
Brain-impermeable SCOT inhibitors offer a targeted approach to treating type 2 diabetes (T2D) while minimizing side effects associated with previous SCOT inhibitors that have CNS related side effects.
As ketones are a major fuel source for the brain, brain-impermeable SCOT inhibitors will preserve the brain’s ability to use ketones as a fuel.
University of Alberta researchers have developed novel SCOT inhibitors with peripheral selectivity and reduced brain penetration. These new chemical entities are designed to specifically block SCOT activity in peripheral tissues rather than in the brain, while still maintaining the glucose-lowering effects seen in obesity with diphenylbutylpiperidines (DPBPs). In T2D obesity models, these new agents inhibit ketone oxidation and improve glycemia, with reduced accumulation in the brain compared to the DPBP, pimozide
Inhibiting SCOT, a key enzyme in ketone oxidation, can reduce hyperglycemia in obesity and T2D. While this effect has been previously demonstrated with antipsychotics like pimozide, these drugs are associated with undesirable effects on the brain. In this context, this invention offers a promising solution to effectively address these previous challenges while maintaining efficacy.
Intellectual property status
Patent already applied for
Transforming discoveries and innovations into reality is a complex and lengthy process. UAlberta’s Technology Transfer Services (TTS) team helps facilitate this journey. Part of the Vice-President (Research and Innovation) portfolio, TTS helps researchers, postdoctoral fellows, staff and students transform innovations and discoveries into reality—moving them out of the university to benefit society, the economy, the world.
Create your free account to connect with University of Alberta, Technology Transfer Services and thousands of other innovative organizations and professionals worldwide
Send a request for information
to University of Alberta, Technology Transfer Services
Technology Offers on Innoget are directly posted
and managed by its members as well as evaluation of requests for information. Innoget is the trusted open innovation and science network aimed at directly connect industry needs with professionals online.
Need help requesting additional information or have questions regarding this Technology Offer?
Contact Innoget support
