- Novel small molecule carbazole compounds effectively inhibit androgen receptor signaling, overcoming resistance to current prostate cancer treatments.
- Broad efficacy against castration-resistant and enzalutamide-resistant prostate cancer addresses critical unmet needs in advanced disease.
- Potential applications extend beyond prostate cancer to other androgen receptor-positive cancers, including breast, ovarian, and fallopian tube cancers.
OVERVIEW
The technology relates to small molecule androgen receptor inhibitors and methods of using the same for treating prostate cancer. The novel compounds have demonstrated efficacy for disrupting androgen receptor signaling and inducing apoptosis in castration-resistant and enzalutamide-resistant prostate cancer cells. Some in vitro data for the lead carbazole compound, SH-I-125, suggests that it is more effective than the clinically significant androgen receptor inhibitors MDV3100 and ARN-509.
BACKGROUND
Prostate cancer is a significant health concern, ranking as the most common cancer among men in 2019, excluding non-melanoma skin cancer. With an incidence rate of 658 per 100,000 males in 2019, it represents a substantial burden on public health. This high prevalence underscores the importance of ongoing research and innovation in prostate cancer detection, treatment, and management. Advances in these areas are crucial for improving patient outcomes and addressing the challenges posed by this widespread malignancy. Innovations in targeted therapies, diagnostic tools, and treatment strategies are continually being developed to enhance the quality of life for patients and increase survival rates.
Benefit
Market Application
Publications
10.6 (2022).
(2023): 1-29.
Granted U.S. Pat. Nos. 10,173,978 and 11,104,646
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