The asset, identified in a double-blind experimental study of myocardial ischemic injury, is a truncated form DJ1∆12 of the DJ-1 protein (PARK7; Parkinson's disease protein 7). Experiments demonstrate the peptide’s ability to protect against organ damage caused by ischemia and subsequent reperfusion of the occluded artery.
Ischemia can occur in different organs (heart, brain, liver, kidney, etc). As a case study,Ischemic Heart Disease affects around 126 million individuals (1,655 per 100,000), which is approximately 1.72% of the world’s population.
Moreover, the molecule has multiple mechanisms of action, meaning that it doesn’t have a single target. Those include the reduction of oxidative stress, mitochondrial damage, cell death and chaperone activity.
Current development status: the asset has been already testedin vivoin mice and rat models. New results are about to be published.
The Sant Pau Institute of Biomedical Research (IIB Sant Pau) is a research centre that holds 9 different entities grouped under one name for strengthening collaborative translational research and for bridging the gap between basic research and clinical practice so as to ultimately improve patient care.
The different entities are based on the Sant Pau Biomedical Campus, where other entities, such as the Barcelona Health Hub (BHH), are working together in the health sector. The most tangible benefits of this collaborative environment are the application of technology to health, and the scientific dissemination of these discoveries.
Members of the IIB Sant Pau:
- Fundació Institut de Recerca de l’Hospital de la Santa Creu i Sant Pau
- Fundació de Gestió Sanitària de l’Hospital de la Sant Creu i Sant Pau
- Fundació Privada de l’Hospital de la Santa Creu i Sant Pau
- Universitat Autònoma de Barcelona
- Fundació Puigvert
- Banc de Sang i Teixits
- Centre Cochrane Iberoamericà
- Equip d’Atenció Primària Sardenya
- Agència de Salut Pública de Barcelona
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