Disclosed is a 3D matrices for in vitro growth of tumor tissues. Recreating a good model of tumor tissue in vitro allows you to
experiment with new formulation anti-neoplastic drugs, to develop the optimal conditions of electroporation as well as the study of the cellular mechanisms underlying the disease.
Disclosed is a 3D matrices for in vitro growth of tumor tissues. Need to prune the system variables using faster and cheaper in vitro assays in order to design the in vivo experimentation on a smaller number of animals, obtaining the following advantages: 1. Speeding up the arrival to the clinical trial 2. Avoiding the sacrifice of animals with ethical and economic advantages. Recreating a good model of tumor tissue in vitro allows you to experiment with new formulation anti-neoplastic drugs, to develop the optimal conditions of electroporation as well as the study of the cellular mechanisms underlying the disease.
Applications
Scaffold that allows to obtain tumor cell growth and cell produced extracellular matrix: the in vitro tissue is extremely similar to the tumor tissue obtained from biopsies (breast cancer). The cells in the 3d matrix experience cell-cell and cell-matrix interactions as in biological tissues, unlike 2d cultures.
Unismart - University of Padua Foundation
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