Universidade de Santiago de Compostela

HIGH-THROUGHPUT CALORIMETRY. Thermal Microsensor with Improved Temporal and Spatial Resolution

Posted by Universidade de Santiago de CompostelaResponsive · Innovative Products and Technologies · Spain

Summary of the technology

The prototype developed within ERC-PoC "ANTS" project, has demonstrated its sensitivity for a new concept of microcalorimeters, as well as providing advantages in microfluidics.
We aim to:
a) Integrate this technology within microfluidic devices or applications where size and fast response time are crucial.
b) Develop a High-Throughput Calorimetry going beyond the current capabilities on ITC.

> Sensing element. Ferromagnetic permalloy line 4x28 µm x 20 nm thick: affordable, miniaturization… Sensor was fabricated in a single deposition.
> Temporal response. Milliseconds, to stimulus >10 microwatts; further improvements are in progress.
> Easy adoption. Compatible with standard configuration of microcalorimeters.

Description of the technology


  1. SPATIAL resolution: due to its tiny size (combined with microdeposition and patterning), it offers a possibility for the integration for microfluidic detectors or other applications where the size and fast response time are crucial.
  2. TEMPORAL resolution: our tests have already demonstrated a milliseconds response to stimulus of microwatts.
  3. THERMAL resolution: the thermal voltage generated scales with the length of the line (irrespective of its thickness); thus, a zig-zag configuration will improve its thermal sensitivity still with micron-size resolution.
  4. Easy adoption: compatible with standard configuration of microcalorimeters.

EXPECTED IMPACT: A novel microcalorimeter with highly improved temporal, spatial and thermal resolution. Thus, ANTS-HTS Calorimeter can be expected to join the ranks of best practices to decrease attrition rates, contributing to reduce the staggering costs of drug development.

Intellectual property status: Patent application number : EP3184981 (A1), US2017268936 (A1), CN107076622 (A), KR20170045252 (A), JP2017532534(A).

Current development status: Laboratory prototypes.

Related keywords

  • Electronics, IT and Telecomms
  • Measurements and Standards
  • Measurement Tools
  • Sensor Technology related to measurements
  • Electronics Related Market
  • Analytical and Scientific Instrumentation
  • Other analytical and scientific instrumentation

About Universidade de Santiago de Compostela

Technology Transfer Office from Spain

The CiQUS (University of Santiago de Compostela, Spain), addresses challenges in Biological and Medicinal Chemistry, New functional Materials and Synthetic Technologies for Sustainable Development.

CiQUS hosts 20 research groups, including 5 ERC projects.
> 90-100 papers/yr, average Impact Factor IF=7,10 JCR. 82%Q1, 45%D1 (2016-2017).
> 2014-2017: 4,70 M €/yr from competitive R&D funds (27% international, 18% private), 16 patents, 2 licenses, 3 spin-offs.

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