CVT Valorisation Sud

Vaccine against bubonic and pneumonic plague

Posted by Zepponi from CVT Valorisation SudResponsive · Innovative Products and Technologies · France

Summary of the technology

Our offer is a vaccine against Bubonic and Pulmonary Plague. It was developed by researcher from the Pasteur Institute of Paris who is a WHO collaborating center on Plague.

Description of the technology

Plague is still a public health problem in the world and is considers as a re-emerging disease. Yersinia pestis the causative agent is also consider as a potential biological weapon, but no efficient vaccine is available.

The pneumonic plague is considered at high risks to initiate outbreaks. Antibiotic treatment is not sufficient to control plague, and resistant strains have recently emerged. The residual plague mortality in endemic countries remains around 10 %.

Researchers from the Pasteur Institute are developing a vaccine, based on a live attenuated Y.pseudotuberculosis expressing important antigenic Y.pestis peptides. Recent study using this vaccine shows 100% protection against bubonic and pneumonic plague in mice with a single dose. Preliminary humoral and cellular response has been successfully observed.



  • Efficiently prevention of a re-emerging disease and a potential bioterrorist weapon
  • Currently no safe and efficient vaccine
  • Induce systemic and mucosal immunity
  •  Rapid and low production cost
  •  Live vaccines: don’t need adjuvant, prolonged stimulation of the immune system.
  •  The research unit is a WHO collaborating center on plague


Technology Owner

CVT Valorisation Sud

Technology Transfer Network

CVT Valorisation SUD

Business Development Manager at CVT VALORISATION SUD

Related keywords

  • Biological Sciences
  • Medicine, Human Health
  • Pharmaceutical Products / Drugs
  • Virus, Virology / Antibiotics / Bacteriology
  • Human vaccines
  • Medical Health related
  • Therapeutic
  • Clinical Medicine
  • Pulmonary medicine
  • infectious diseases

About CVT Valorisation Sud

Technology Transfer Network from France

The "Valorisation Sud" Consortium (CVT) is an inter-institutional organisation certified within the framework of investments for the future. With a ten-year endowment of €9 million, the CVT Valorisation Sud is the French national reference organization for transfers of technology and know-how adapted to tropical and equatorial regions and developing countries.

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