This invention introduces a novel method for preparing poly(D,L-lactide-co-glycolide) copolymer (PLGA) compositions using non-toxic glycofurol as a solvent. The resulting PLGA constructs exhibit very low residual glycofurol and provide unexpectedly prolonged in vitro and in vivo release of incorporated drugs. This approach eliminates the need for toxic solvents like chloroform and dichloromethane, offering a safer and more effective drug delivery system. The technology enables extended release of both hydrophobic and hydrophilic drugs, including antibodies, expanding its potential applications in various therapeutic areas.
BACKGROUND
PLGA is widely used in drug delivery systems due to its biodegradability and FDA approval. However, traditional PLGA formulations often use toxic solvents, leading to side effects such as sterile abscesses, pain, and swelling. These formulations also struggle with short drug release durations and limited efficacy with hydrophilic drugs. This invention addresses these challenges by using glycofurol, a non-toxic and biocompatible solvent, to create PLGA compositions with extended drug release capabilities and improved safety profiles. The technology offers a versatile platform for developing long-acting formulations for various conditions, potentially improving patient compliance and treatment outcomes.
Benefit
Market Application
Publications
PCT/US2024/010868
Preparation of PLGA Microspheres Using the Non-Toxic Glycofurol as Polymer Solvent by a Modified Phase Inversion Methodology. Polymers. 2024; 16(3):434. https://doi.org/10.3390/polym16030434
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