Patrick Claude, PhD.

Research Organic Chemist, Medicinal Chemistry Consultant, Instructor and Tutor in Chemistry, Math, French at Dallas Fort Worth Formatec Learning Center

United States · Dallas TexasJoined July 2017



Research Experiences

Several years of experience in synthetic methodology, small molecules, multi-step synthesis, optimization of reaction conditions of small to large scale synthesis of natural compounds that have application to SAR, Bio- Conjugation, Biopharmaceutical, as well as agricultural chemistry applications.

Four years’ experience Consulting in Heterocyclic Chemistry and Natural Products for devising and advising efficient synthesis of Beta-Lactams, (Applicable to Carbapenems), Benzodiazepines, various classes of Heterocyclic Alkaloids, Terpenes, Sesquiterpenes, Asymmetric Synthesis, Synthesis of small molecules and medium complex intermediates, amino acid derivatives, short peptides, Peptidomimetics, Carbohydrates, and compounds as Active Pharmaceutical Ingredients, (API).

Several years’ of experience in manipulating air sensitive compounds, and the use of organo-metallics such as Rhodium, Cobalt, and Palladium, Organisilicon for synthesis of various compounds. Use of palladium complex reagents to carry Heck, Susuki, Stille, Sonogashira coupling and intramolecular reactions for Carbon-Carbon bond formation in synthesis of Cyclic Acetogenins

Achieved, and conceived multi-step synthesis of natural product synthesis of cyclic compounds such as terpene, sesquiterpene, C-C bond formation, asymmetric synthesis of small molecules, natural products, synthesis of heterocyclic compounds, lipids, glycolipids, and glyco- amino lipids compounds. Achieved synthesis of complex cyclic acetogenins as pesticides and fungicides for crop protection, cross metathesis reactions, coupling and cyclization reactions with palladium complexes.

Several years of experience in Carbohydrate Chemistry, modification of Carbohydrate, Functional Groups Modification. Elaborated, conceived and achieved synthetic methodology for construction of difficult glycosidic bonds by a synthetic methodology called Intramolecular Glycosylation unrealizable by conventional glycosylation. These glycosidic bonds are present in many natural compounds that display interesting biological activities as anti-cancer, anti-cardiac agents and anti- viral agents, such as Saponins, Glyco-Anthracyclines and various other glycoconjugates, application to Carbohydrate Polymers, Carbohydrate Dendrimers, Oligosaccharide Synthesis, Protein Binding, Biocatalysis,

Two years’ experience in Process Chemistry, worked in clean GMP laboratories in medium to large scale of monosaccharides, disaccharides, trisaccharides, to be used for preparation of polysaccharides vaccines.
Applicable to Synthesis of Carbohydrate Polymers, Carbohydrate Dendrimers, SAR Analysis, Bioconjugation, and Guar Gum Synthesis and Click Chemistry.

Experience in Process Chemistry, Process Optimization, and Generation Process Data, worked in clean GMP Laboratory Clean Room. In medium large and large scale of diverse monosaccharides, small molecules for preparation of large glycoconjugates vaccines. Writing reports in Laboratory notebooks in SOP model strictly conform to GMP Regulations. Achieved parallel synthesis of various natural products, heterocycles, carbohydrates, and glycoconjugates.

Experienced in synthesis of amino acids derivatives, solution and solid phase synthesis of peptidomimetics.
Applicable to Peptide Nucleic Acids, (PNA), and Protein Chemistry.


More than ten years’ experience in characterization of compounds by using 1D-NMR, 2D-NMR (H-H COSY, C-H COSY, HMBC, TOCSY, ROESY, etc.), Mass, IR-UV spectroscopy.
Many years’ experience in techniques of purification and separation of many classes of compounds by analytical and preparative HPLC, Standard and Reverse Phase Chromatography, Flash Chromatography, GC-MS, LC-MS. Several year of experience and knowledge in the utilization of chemistry search program soft wares such as Sci-Finder, Reaxys, File Registry Chemical drawings (STN) and CAPLUS File Registry, Chemsketch, Chemwindows, Chemdraw, NMR-programs to retrieve and process 1 -and 2 –dimensional NMR spectrums. Others: PowerPoint, MS-Word, Word Perfect, Excel, Windows 1998, 2000, 2003-2013.

Successful years of experience working as a chemistry lecturer and tutor
Sound knowledge and understanding of instruction theory and practice.
Ability to work collaboratively with administration and colleagues.
Excellent oral and written communication with leadership qualities.
Strong interpersonal and organizational skills.
Excellent motivation and instructional skills.
Many years’ experience in developing questions for Examinations with comprehensive rationale,
as well as correction of examinations.
Many years’ experience in tutoring Sciences General Chemistry, Organic Chemistry, Advanced Organic Chemistry, Physical Chemistry I, (Thermodynamics), Analytic Chemistry, (Quantitative Analysis), High School Chemistry, AP and Normal Level, Mathematics, (Algebra I , II, Trigonometry, Pre-Calculus) , French Tutoring to College, High School , Junior High School and School Level Students.
Fluent in English, French, German, (speaking and writing), have taught, tutored in all three languages.

Junior Patent Examiner Experience

Junior patent examiner in Organic Chemistry, Biotech, Pharmaceutical.
Skills of patent examining applications for scientific inventions, search of prior art by using multiple scientific and patent search software toward finding prior art. Use of scientific specialty to determine prior art, patentability or non-patentability of organic chemistry inventions pertaining to Biotech-Pharma.

Work Experience (1)

Medicinal Chemistry Consultant

SV ChemBiotech, Inc

April 2010 - July 2016


Academic Studies (1)

Dr.rer.nat Organische Chemie, PhD. Organic Chemistry

Eberhard-Karl- University of Tübingen, Tübingen, Germany

January 2000 - January 2005

Organic Chemistry

Carbohydrates & Glycoconjugates:
Developed and devised the total stereo and region-selective synthesis of cyclic disaccharides by Intra-molecular Glycosylation, an efficient methodology to create difficult glycoside linkages present in natural glycol-conjugates; unachievable by the conventional glycosylation method. The cyclic products can be transformed into Saponins, large classes of glycoconjugates that bears terpepnes, triterpenes, steroids, production and construct polysaccharide vaccines, various glycoconjugates, and dendrimers of medicinal importance. Applications to SAR, and Bioconjugation. Purification and separation of compounds by analytical and preparative HPLC, Standard and Reverse Phase Chromatography, Flash Chromatography.
Characterization of compounds by using 1D-NMR, 2D-NMR (H-H COSY, C-H COSY, HMBC, TOCSY, ROESY, etc.), GC-LC-MS, MS, IR-UV spectroscopy.

Full Time Adjunct Professor in General, Organic and Advanced Chemistry Laboratory, and Exercises Classes (PhD. Candidacy Years)
Five years teaching experience as Full Time Adjunct Professor in lecturing and assisting graduate and undergraduate candidates in laboratory experiments in General, Organic and Advanced Organic Chemistry at Eberhard-Karl- University of Tübingen, Germany. Experienced in mentoring and providing guidance Master and Bachelor’s candidates insights in their research projects in laboratory experiments and recent chemical analytical instrumentations including writing their thesis. Experienced in preparing, rationally writing examinations, as well as correcting examination and laboratory reports of undergraduates and graduate candidates.
Developed and maintained student’s interest in chemistry by organizing various exercise sessions.
Worked towards improving student participation in exercise lectures. Provided a positive environment in motivating student. Ensured to maintain excellent group management.
Laboratory Management for instruments, material resources in chemicals that is reagents, solvents, acids, bases for continuous flow and needs to ensure continuous carrying of experiments.
Managed laboratory safety by teaching and advising candidates the use of flammable solvents, acids, bases.
Coordination for budget management of our laboratory for new computer software, analytical instrumentation, new chemicals, management of laboratory spending, coordinate invitation specialist from corporation to hold seminar regarding the use of most recent analytical instruments.

Research areas of interest (14)

  • Physical Sciences and Exact Sciences
  • Chemistry
  • Organic Chemistry
  • Petrochemistry, Petroleum Engineering
  • Pharmaceutical Products / Drugs
  • and 9 more

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