Ideaya and GSK partner on synthetic lethality programs



25 June, 2020   News

This article was originally published by The Science Advisory Board staff writers on the digital media The article has been replicated on Innoget's Innovation Blog by Innoget's Editorial Staff for information purposes.

Ideaya Biosciences and GlaxoSmithKline (GSK) have formed a strategic partnership in the emerging oncology field of synthetic lethality.

Synthetic lethality occurs when the combination of two or more genes are deficiently expressed, resulting in cell death. The phenomenon can be used to exploit tumor-specific vulnerabilities through medicines for patients with cancer.

The partnership between Ideaya and GSK will advance Ideaya's synthetic lethality programs for MAT2A, Pol Theta, and Werner Helicase, which are expected to advance to clinical trials within the next three years. The company has already solved the crystal structures for all three compounds and demonstrated in vivo proof of concept in animal models for MAT2A and Pol Theta.

As synthetic lethality is one of four core focus areas for GSK in oncology, the partnership will allow it to build a synthetic lethality pipeline for targets of molecularly defined populations for several major solid tumors.

Under the agreement, Ideaya will lead the MAT2A program through early clinical development and is responsible for all costs of the MAT2A program prior to the GSK option exercise. Moving forward, the company will be responsible for 20% of global development costs.

Ideaya will receive 50% U.S. profit share and ex-U.S. royalties for the MAT2A and Werner Helicase programs and is responsible for 20% of global development costs for licensed products being developed with GSK. Ideaya will receive global royalties for the Pol Theta program, and GSK will cover all research, development, and commercialization costs. GSK will be responsible for all commercialization activities and global costs for licensed products.

Keep up to date on Innoget's initiative to beat Covid-19 by following the dedicated channel where new innovation needs, novel technologies, news, and events are posted daily.

Other News

SHV Energy Launches New Open Innovation Portal

  • 23 April, 2021

Innovation and an ecosystem of partners are crucial in our mission to Advance Energy Together, providing cleaner energy for all. SHV Energy launches an open innovation portal to find new partners to co-develop innovative solutions, find new ideas and create mutual opportunities. As a global energy group we recognise, and embrace the challenge to continue to provide essential energy solutions to off-grid customers that are envir...

Read more about this

  • 21 April, 2021

In the framework of this collaboration, we have issued a new challenge to the innovation ecosystem, focused on the digitalization of the circular economy flow. Currently, there is a growing demand in the market for packaging containers or products elaborated from recycled materials. Thus, we need to identify solutions that help us certify that the raw materials we produce from waste at the Valoriza Servicios Medioambientales (VSM) plants are i...

Read more about this

  • 16 February, 2021

EINST4INE - The European Training Network for Industry Digital Transformation project will explore various aspects of #digitaltransformation spread across interconnected research areas such as: ...

Read more about this

Find More News