Lilly begins phase III trial for COVID-19 therapy

News

FacebookGoogleLinkedInTwitter

19 June, 2020   News

---
This article was originally published by The Science Advisory Board staff writers on the digital media scienceboard.com. The article has been replicated on Innoget's Innovation Blog by Innoget's Editorial Staff for information purposes.
---

Eli Lilly has enrolled patients in a phase III study to evaluate the efficacy and safety of baricitinib in hospitalized adults with COVID-19.

Baricitinib, marketed by the company as Olumiant, is an oral Janus kinase (JAK)1/JAK2 inhibitor licensed from Incyte that has been approved in 70 countries as a treatment for rheumatoid arthritis.

COVID-19 can be associated with a hyperinflammatory state and JAK1/JAK2 inhibition may reduce the cytokine storm caused by SARS-CoV-2 infection. In addition to being a JAK1/JAK2 inhibitor, baricitinib may also inhibit cell host proteins that assist in viral reproduction, thereby reducing the ability of infected cells to produce more virus.

Lilly expects to enroll 400 patients in the randomized, double-blind, placebo-controlled study. The study will be conducted in the U.S., Europe, and Latin America and will include patients hospitalized with SARS-CoV-2 infection who have at least one elevated marker of inflammation but who do not require invasive mechanical ventilation. Patients will be dosed with 4 milligrams of baricitinib daily or placebo for up to 14 days or until discharge.

Upon successful approval for use of baricitinib in COVID-19, Lilly will continue to create adequate supply to support both appropriate clinical and investigational use.

This study will complement data from a study of baricitinib with remdesivir in the second phase of the Adaptive COVID-19 Treatment Trial (ACTT-2) run by the National Institute of Allergy and Infectious Diseases, part of the U.S. National Institutes of Health.

---
Keep up to date on Innoget's initiative to beat Covid-19 by following the dedicated channel where new innovation needs, novel technologies, news, and events are posted daily.

Other News

  • 21 April, 2022

Nomad Foods has partnered with the global innovation network Innoget to launch an open innovation portal to accelerate food tech collaborations. The portal will expedite solutions for some of the most pressing challenges facing the food industry, such as exploring new protein and packaging technologies, the Birds Eye parent said. It will be open to academics, subject experts, start-ups and SMEs that aim to develop new partnerships, beginnin...

Read more about this

Research and Development at PepsiCo changes the world, quite literally

  • 11 April, 2022

Shape the future at PepsiCo. Our scientists, technologists, and engineers are breaking new ground to make a positive impact on both consumers and our planet. R&D’s objective at PepsiCo is to shape the future by delivering a wide range of innovative foods and beverages—for brands like Frito-Lay, Gatorade, Pepsi-Cola, and Quaker —being one step ahead of consumer demand while raising the bar on sustainability. We proud...

Read more about this

  • 07 April, 2022

Luxembourg’s public research community is characterized by a spirit of agility and cooperation. Its most recent initiative aimed at facilitating the development of partnerships and promoting technology transfer is the launch of a digital platform for open innovation. Creating bridges between research and industry is high on the agenda of Luxembourg’s public research institutes. “Our culture of partnership and Knowledge and...

Read more about this


Find More News