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 | Seeking Solutions for Repair and Protection of Enamel and Dentin |
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A product that delivers significant and long lasting repair to damaged tooth enamel and dentin |
 | Seeking Next-Generation Equipment and Processing Technologies for Tempura Batter-Coated Fish Products |
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Nomad Foods is seeking innovative equipment, processing technologies, or integrated solutions that enable the development of next-generation tempura batter-coated fish products. By “conventional” battering and coating systems, we mean standard waterfall/curtain batter application combined with static frying or baking, which limits coating uniformity, consistency, and yield at scale. We are looking for solutions that demonstrably improve on this baseline by delivering: a more even and well-adhered batter coating across irregular fish portions, reduced batter loss/waste during application, and greater batch-to-batch consistency of coating weight and texture. We expect proposals exclusively from commercial technology providers — equipment manufacturers, engineering firms, technology start-ups, and system integrators with deployable or near-deployable solutions. Academic institutions or research groups without a commercial product, prototype, or industrial partner are not the focus of this call. By “improve robustness” we mean equipment and processes that maintain consistent coating performance despite normal variability in raw material (fish portion size and shape), batter viscosity, and line speed, with minimal downtime or operator intervention. By “flexibility for integration” we mean compatibility with our existing battering/coating and freezing lines: solutions that can be retrofitted or integrated without requiring a full line replacement, and that can accommodate multiple product formats (fillets, portions, nuggets) on the same equipment. |
| | Seeking Biomanufacturing of Transformational Ingredients in Consumer-Packaged Goods |
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We are looking for approaches to engineer and optimize organisms (microbial and plant) for production and/or purification of relevant biomolecules in a non-trial-and-error format. It is believed that starting from a waste stream will be a more cost-effective solution. We are also interested in plant- or algae-based solutions that are scalable and cost effective. What We Are Looking For: • Strain engineering approaches that achieve target molecule production targets across multiple molecule classes in significantly less time versus the industry average • Host engineering capabilities in non-model systems • Scale up platforms/methods that are amenable to commodity scale ingredients • Downstream processing methods/technologies that facilitate continuous extraction and/or re-use of extractive reagents • Approaches that leverage feedstocks separate from the food chain |
 | Stable inhibitors of the 5-lipoxygenase pathway for treating Asthma and Cancer |
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The University of Leipzig has patented a series of Carborane-Based Inhibitors of the 5-LO Lypoxygenase pathway. These inhibitors are selectively cytotoxic towards several leukotriene-dependend melanoma and colon cancer cell lines., while leaving non-malignent cells intact. Furthermore, these inhibitor analogues have shown co-inhibition of heat shock proteins necessary for tumor development in such cell lines. Experimental results on mice showed promising results. Moreover, since these compounds have a high content of boron, they may also be suitable for Boron Neutron Capture Therapy (BNCT), a binary cancer therapy that uses selective boron compounds and thermal neutrons. Furthermore, leukotriene inhibition could be useful in the treatment of asthma, as their production is related to inflammatory responses. The BBZ is looking for organzations interested in acquiring this technology offer, helping perform precilinical and clinical studies, and ultimately leading to the licensing of it. |
 | NanoMEDIC gene editing delivery system |
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Background Gene therapy holds great potential for the treatment of genetic diseases. However, delivery to specific tissues is still a major bottleneck. Although AAV-delivered CRISPR-Cas9 editing is being developed for multiple diseases, its therapeutic translation is hindered by the limited packaging capacity of viral particles and possible immune response to them. Moreover, AAV transgenes tend to be expressed for an extended period of time, which increases off-target mutagenesis risk. Extracellular vesicles (EV) is another option and, when combined with ribonucleoprotein (RNP) delivery of CRISPR-Cas9, reduces off-target effects. The structural polyprotein Gag is typically used to package cargo into EVs, which nevertheless limits the EV packaging capacity. The present invention is an all-in-one EV delivery system termed NanoMEDIC (nanomembrane-derived extracellular vesicles for the delivery of macromolecular cargo). It is a transient EV-based CRISPR-Cas9 editing delivery system which ensures efficient genome editing in various cell types. |
 | Device for non-destructive and rapid permeability measurement |
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Many products require determination on how easily can fluids penetrate through the sample material. A precise and rapid measurement of the permeability is therefore crucial in many applications in the fields of freeze-dried products (pharmaceutical and food industry), textile industry, filter and membrane material manufacturers, additive manufacturing (3D printing), artificial bone implants, composite producers… Our innovation provides in-situ determination of the permeability, quick & real-time measurement (< 1 sec.), non-invasive, non-destructive method, and appropriate also for fragile materials. Applicable for: filters, membranes, freeze-dried products, textiles, composites, artificial bone scaffolds… |
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