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Otava Institute is a global provider of one-stop integrated research solutions for business and life science. Our team includes chemists, biologists, physicists whose combined efforts contribute to the complex contract research projects for pharmaceutical, agro, cosmetic and material science industries.We are dedicated to providing clients with outstanding service in these key areas and will continue to push boundaries to remain an industry front-runner. Each day we expand our core competencies delivering of new technologies to meet all the customer’s needs.
Our location in Toronto Ontario, Canada provides our clients with the added advantage of North American IP rules and regulations and secure communication and logistics. Our Ukraine – based R&D facilities represented with the Ukrainian Laboratories, that is cooperating with leading Ukrainian research institutions and carries out research work in the format of outsourcing.
We work as a preferred partner to many of the world’s top 10 pharma firms, and hundreds of other companies, providing support with creative solutions for complex technical compound issues. Our scientific knowledge, combined with our research and manufacturing capability, enables us to support chemical processing and production without ever compromising on quality.
Our experience, dedication, and commitment to quality make us an ideal partner for discovery stage research.
SARS-CoV-2 RNA-dependent RNA Polymerase (RdRp) Targeted Library provides with the 1017 small compounds with predicted activity against SARS-CoV-2 RdRp.[…]
Selective estrogen receptor modulators (SERMs) are compounds that act on the estrogen receptors (ERs). This library comprises drug-like compounds only (PAINS compounds are filtered off) and provide an excellent basis for drug discovery projects related with ERs.[…]
The Matrix metalloproteinase-2 (MMP2, gelatinase A, 72 kDa type IV collagenase) is involved in different functions such as reconstruction of the vasculature, angiogenesis, tissue repair, inflammation, tumor invasion and atherosclerotic plaque rupture. Mutations in the MMP2 gene are associated with T[…]
RNA is essential for transcriptional regulation, translational regulation, protein function, and catalysis, responsibilities that have classically been reserved for proteins. It also highlights the potential of targeting RNA for treatment of a multitude of diseases including bacterial/viral infectio[…]
Protease-Oriented SARS-CoV-2 Library (1017 Compounds) - Developed by Virtual Receptor-Based Screening Using the Crystal Structure of the Basic SARS-CoV-2 Protease (PDB ID: 6LU7) ML (Machine Learning) SARS-target library (1577 compounds) - carefully developed using machine learning (artificial neura[…]
OTAVAchemicals offers Catechol O‑Methyl Transferase (COMT) Targeted Library. It contains 504 compounds with predicted inhibitory activity against this enzyme. The library has been carefully designed with combination of ligand- and receptor-based pharmacophore modeling.[…]
Viral RNA-dependent RNA Polymerases (RdRPs) Targeted Library (1259 compounds) with predicted activity against viral RdRPs is offered. It has been carefully designed using machine learning (artificial neural networks and Bayesian statistics[…]
OtavaResearch Institute group presents SARS-CoV-2 RNA-dependent RNA Polymerase Targeted Library (1031 in-stock compounds with predicted activity against SARSCoV2 (RdRpp)).[…]
Using receptor based virtual screening OtavaResearchInstitute’s team designed the SARS-CoV-2 Papain-like Protease PLpro Targeted Library, which is contain 1058 stock compounds with predicted activity against this protease and ready for delivery.[…]
SARS-CoV-2 2′-O-methyltransferase (NSP16) Targeted Library, which contains 1049 compounds with predicted activity against SARS-CoV-2 NSP16 is offered. The library has been designed with receptor-based virtual screening using crystal structure of SARS-CoV-2 2′-O-MTase (PDB ID: 6WKQ).[…]
The offer SARS-CoV-2 Helicase (NSP13) Targeted Library, which contain 1170 compounds with predicted activity against this vital protein. The overall procedure included accurate flexible docking of Drug-like Green Collection into helicase active site.[…]
Our offer is a chemical optimization service - synthesis of two-target specific set of pyrazolo[3,4-d]pyrimidine derivatives as dual-targeted inhibitors of HDAC1 and mTOR. We will synthesize these novel analogs only upon your request.[…]
Our company offers the chemical optimization service - synthesis of a unique DHFR targeted set of novel arylpiperazine derivatives for your biological projects, related to developing of anti-toxoplasmosis drugs.[…]
To provide purification from methane (deep oxidation of methane) at relatively low temperatures (about 400 °C), Ukrainian Laboratories propose the technology based on several innovative approaches.[…]