Knowhow and Research output Technology Offers

Know-how and Research output from top scientists and innovators, including know-how submitted for an abandoned patent and research for which no patent was filled

Yissum - Research Development Company of the Hebrew University posted this:

Briefly, Some of the degenerative diseases associated with aging (such as Parkinson's Disease, Alzheimer's Dis., Congestive heart failure and more) are caused by decrease in the removal of defective mitochondria; a quality-control process known as mitophagy. The current technology/concept will enable the restoration of mitophagy efficiency, thereby prevent the evolvement of age-related degenerative diseases. As such, it can be used as a treatment; which is a major medically unmet need. The concept: Spermidine (Spd) is a natural polyamine regulating important and diverse physiological processes such as cell growth, cell proliferation, and programmed cell death. The concentration of Spd is decreasing with age in mammals hence it was suggested to adapt a dietary supplementation of Spd to compensate for the natural loss with age and thus support healthy aging. However, the usefulness of Spd as a drug is limited because it can be degraded by gut-associated bacteria and its excessive accumulation inside mammalian cells can result in toxic product formation. And this is exactly where the 6443 (Novel small molecules that facilitate mitophagy ) kicks in. the team suggests to synthesis parallel molecules that mimic this MOA or at least by applying them you receive the same effect of restoration. As of today, several applications have been submitted lately by the group in order to demonstrate the superiority of healthspan of these novel set of stable polyamine-like compounds (compared to native Spd),. Current status: the research was funded by the HUJI funds (קרן המחקר לגימלאים ) resulting with a preliminary findings as specified below. In addition, pre-proposal already sent to the Israeli Ministry of Science and similar. One will be soon submitted to ERC PoC Grant. Based on Ariela, the team would like to have FTO and mainly being able to speak this notion. Conclusion: Following Tami’s email, a conversation I had with Ariela and the materials handed by the researchers it is not possible to review the technology/matured concept further due to lack of information/data. The studied as conducted so far were based on in vivo exp., with Caenorhabditis elegans nematode, which is extensively used as a model organism. The goal was to explore the potency of five compounds as mitophagy-inducers using imaging experiments. The researchers identified successfully two compounds that induced mitophagy (MAC1* and MAC4*) where MAC4 was superior to MAC1 and both Project ID : 6-2018-4576