Cracow University of Technology posted this:Bioactive hydrogel wound dressings with nanosilver.The main aspect of innovation, which can be implemented in industrial practice, is application of degradable polymers, while maintaining the usable equivalence to current products. It is associated with a tendency to reduce environmental consumer waste. Specialized wound dressings are now one of the most profitable medical devices. Their variety of assortment and implementation of more niche application solutions demonstrate the ability of their wider application. It is assumed, that annual sales of specialized dressings on the markets in 2010-2015 will increase by about 4%.
Cracow University of Technology posted this:Synthetic bone substitute with antimicrobial properties (antibacterial and antifungal).The offered product is a material used for reconstruction of skeletal system bone with long-term antimicrobial operation, in contrast to the pure hydroxyapatite most widely used in regenerative medicine. The resulting materials can be designed in many industries, but the emphasis is mainly focused on medical, dental and pharmaceutical applications.
Cracow University of Technology posted this:Hydrocolloid nanocomposite and production method thereof. Product is dedicated for superficial wounds in a shape of platesNanostructured silver is suspended in the gelling environment, which is a precursor of a colloidal system. A gelatin which is a natural protein polymer is a gelling environment. Nanosilver, due to its characteristics is widely used. The best-known advantage of silver nanoparticle is its antibacterial activity.
University of Vigo posted this:Pyridazin-3(2H)-one Derivatives as Selective Inhibitors of Monoamine Oxidase-B Isoform (MAO-B)The pyridazine ring is a privileged fragment found in compounds with very different pharmacological properties, such as antihypertensive, antiplatelet, anti-inflammatory, antinociceptive, antidepressant, hypoglycemic, antiinfective or anticancer agents, many of them being pyridazin-3(2H)-one derivatives. The pyridazine ring is also included in polycyclic compounds acting as MAO-B inhibitors. However, simple pyridazin-3(2H)-one derivatives have not been described so far as selective MAO-B inhibitors. The present invention provides novel pyridazin-3(2H)-one derivatives substituted at C4, C5 or C6 with several dithiocarbamate moieties that selectively inhibit the MAO-B activity and whose structure is unrelated to those currently available.
University of Vigo posted this:Procedure for the extraction of biosurfactants contained in corn steep liquorsNowadays, most of the pharmaceutical and cosmetic products in the market contain chemically synthesized surfactants in its composition. In many cases, these surfactants are the same as those used in regular cleanup activities. In order to get more natural and biocompatible products, it would be interesting to include natural surfactants instead of chemical surfactants in the preparation of these pharmaceutical and cosmetic products. These biosurfactants are also present in the formulation of greener nanoparticles, replacing the chemical surfactants currently used in the preparation thereof. Most biosurfactants have antimicrobial activity, which would improve the properties of certain nanoparticles, as well as many pharmaceutical and cosmetic products. The main disadvantage of biosurfactants industrial production is related to the high cost compared to chemically synthesized surfactant production. The solution proposed by the Chemical Engineering research group at the University of Vigo, is the development of eco-friendly simple extraction of biosurfactant from a corn wet-milling industry byproduct, such as corn wash liquors, better known as "corn steep liquor (CSL)", which could compete in terms of cost production with its chemical counterparts.
Universidad de Alcalá-OTRI posted this:New therapeutic agents for the treatment of inflammatory disordersThe research group, « Heterobetaines », from Alcalá University in colaboration with the research group « Hipersensibility to medicines and inmmunitary innate response » form IDI La Paz, present a new generation of inhibitors of alfa tumoral necrosis factor (TNF-α) production, useful to prevent and / or treat inflamatory diseases. The group is looking for technical cooperation or license agreements with pharmaceutical companies, research centers or diagnostic and treatment against inflammatory diseases research institutions.
Institute of Chemical Research of Catalonia posted this:Crysforma: services in pharmaceutical solid state developmentCrysforma provides complete scientific support for the discovery, analysis and scale-up of polymorphs, hydrates, amorphous phases, salts and co-crystals of active pharmaceutical ingredients or intermediates. Crysforma has developed its own crystallization screening methodology based on the combination of several crystallization procedures. We use high-throughput crystallization systems controlled by highly skilled scientists to maximize the information drawn from each experiment. Our projects are always carried out in close collaboration with the client, adapted to the customer's needs and under strict confidentiality conditions.
Barcelona Skin Genomic posted this:Dermatological pharmaceutical composition for the treatment of skin inflammatory diseases, such as dermatitis and atopic dermatitis (Psoriasis, Acne and Itchy Skin)Dermatological formulation, composed of pharmaceutical compounds, antioxidant molecules and additional active ingredients are developed by Barcelona Skin Genomic to treat inflammatory skin diseases with high efficacy during treatment of atopic dermatitis (AD) with high Scoring Atopic Dermatitis (SCORAD) index, Psoriasis, Acne and Itchy Skin.
Centre Technology Transfer CITTRU posted this:Novel antiviral agent based on modified chitosanThe subject of the new invention is new drug developed by researchers of the Jagiellonian University is intended for treatment and prevention of viral infections caused by coronaviruses in humans, including respiratory diseases manifested by impaired respiratory function – application in biotechnology & medicine.
IMIM Institut Recerca Hospital del Mar posted this:A TREATMENT FOR TRIPLE NEGATIVE BREAST CANCERTriple negative breast cancers are tipically associated with por prognosis, due to aggressive tumor phenotype(s), only partial response to chemoterapy and present lack of clinically established targeted therapies and respresent the focus of increasing interest at the clinical, biological and epidemiological level, as disclosed in Podo et al., Triple –negative breast cancer: Present challenges and new perspectives, Mol. Oncol., 2010, 4, 209-229. There is, thus, a particular need for new active agents suitable for breast cancer treatment, and in particular need for triple negative breast cancers.
JPT Peptide Technologies posted this:Custom Peptide SynthesisJPT Peptide Technologies has a substantial, long-standing expertise in custom peptide synthesis services, providing custom peptides with highest quality for even complex or unusual peptide sequences. If you would like to order a quality peptide synthesis service using regulated processes, choose JPT! Furthermore, our peptide synthesis service has a very high success rate (over 99%) as JPT has developed the know-how to choose and optimize the appropriate synthesis method for each peptide. We go the extra mile to get your peptides done!
Universidad de Alcalá-OTRI posted this:Synthesis of dendritic systems of nanoscopic size for applications in biomedicineRegarding the cationic systems developed, the principal innovative aspects are the following: - They are non viral nanoscopic synthetic molecules able to internalise nuclear material inside different cellular lines. This turns them into good candidates to be considered as non viral vectors in gene therapy processes. - They are non toxic in a concentration range adapted for the accomplishment of different biomedical studies. - They present antibacterial properties against gram + and gram- bacteria - They are able of interacting, in a electrostatic way, with anionic drugs which turns them into drug delivery systems. - They present a hydrophobic carbosilane skeleton that allows the molecules to cross the cellular membranes with major facility. - They are soluble in water. Regarding the anionic systems developed, the principal innovative aspects are the following: - They have an important antiviral capacity - They are able to inhibit the infection for HIV - They have antiinflammatory capacity - They are good candidates for the production of a microbicide gel of topic use that prevents the infection of the virus across sexual transmission.
IMIM Institut Recerca Hospital del Mar posted this:New drug for steatohepatitis treatmentA new alternative treatment for steatohepatitis has been developed; it consisits on new series of amides of fatty acids with fenilalquilamines (amphetamines, dopamine, etc.) A new mechanism of action based in reductions of consumption is exploded: activation of reduce intake and oxidative stress antagonism.