Universidad de Alcalá-OTRI posted this:Salts of pyridazino[2,3-a]pyrrolo[2,1-c]quinoxaline for the treatment of leishmania infections and diseases that involve the protein tyrosine phosphatise 1B (metabolic syndrome, diabetes and obesity)Research groups from the Department of Organic Chemistry and Inorganic Chemistry and the Department of Systems Biology of the University of Alcalá have developed pyridazino[2,3-a]pirrolo[2,1-c]-quinoxalinium salts as therapeutic agents in the treatment of leishmaniasis, metabolic syndrome, diabetes and obesity. The compounds exhibit high activity and selectivity for the Leishmania parasite, and they provide a new therapeutic tool for the treatment of type 2 diabetes. The group seeks pharmaceutical companies to reach licensing agreements or collaboration and commercial agreements with technical assistance.
Centre Technology Transfer CITTRU posted this:Manganese-lactoferrin complex stimulating the growth of probiotic bacteriaThe subject of the offer is manganese-lactoferrin complex with properties stimulating the growth of probiotic bacteria in digestive system. Possible applications of the invention include prevention and treatment of bacterial infections (including sepsis in newborns), chronic inflammatory bowel diseases, dietary supplementation in prevention of bacterial infections and some other indications.
Centre Technology Transfer CITTRU posted this:Staphylococcus pseudintermedius & bacteriocins – various applicationsThe subject of the present offer is new bacterial strain Staphylococcus pseudintermedius Sp222, isolated from dog pathologic dermal lesions. The offer includes also peptide and protein bacteriocins produced by S. pseudintermedius Sp222. These bacteriocins exhibit a broad spectrum of biological activities: - bacteriocin BacSp222 is able to kill a variety of Gram+ bacteria strains, including the methicillin resistant S. aureus (MRSA) strain. It is also cytotoxic towards selected eukaryotic cells and is resistant to action of proteolytic enzymes (either eukaryotic or prokaryotic) as well as to high temperature. The biological activity of BacSp222 is sustained even after limited fragmentation of its molecule by chemical reagents; - lysostaphin Sp222 has an ability to effectively lyse (and, in consequence, to kill) the cells of Gram+ bacteria.
DIT Hothouse posted this:Optimisation of Posterior Spinal Dynamic (PSD) Stabilisation SurgeryOptimising spinal surgery techniques through the use of a hip and spine simulator and a tension and torsion test machine to treat spinal patient such as those with crushed vertebra and spinal deformities, like scoliosis.
Universidad de Alcalá-OTRI posted this:Estimated binding energy model based in Quantitative Structure-Activity Relationships (3D QSAR), for the pharmaceutical industryA research group from the Pharmacology Department of Alcalá University has develop a technology that consists in a model to estimate the interaction energy with the receptor of a pharmaceutical compound that permits the prediction a priori of the activity of new compounds before their synthesis. The model, based on the 3D QSAR method uses application techniques for the study of the behavior of macromolecules and drug design. The group is looking for technical cooperation or commercial agreements with technical assistance.
Universidad de Alcalá-OTRI posted this:Heterogeneous NCH complex of palladium and their uses as recoverable catalysts.AA research Group from the Department of Organic Chemistry and Inorganic Chemistry at University of Alcalá (Spain) has designed catalysts suitable for organic synthesis processes based on supported N-heterocyclic carbene (NHC) complexes of palladium, which are magnetically separable after their use, reusable and resistant to metal leaching, and useful in carbon-carbon coupling reactions. The group is looking for companies in the chemical and pharmaceutical sectors to reach licensing agreements or collaboration and commercial agreements for technical assistance.
Science and Technology Park
STEP RI d.o.o. posted this:Ultrasonic diagnosis of water in lungsUsage in the diagnosis of lung disease due to the specific organ structure is limited comparing to the examination of other organs. With this technology, beside the possibility to use it as a non-invasive diagnostic tool for lungs it also offers opportunity to monitor the effectiveness of medical treatment and to adjust right cure and dose for further treatment of lungs.
Universidad de Alcalá-OTRI posted this:Improved procedure to obtain active principles in Aloe leavesA technology based firm, set up by researchers of Alcalá University, has developed a procedure to obtain active principles from Aloe leaves. With this procedure, a product with pharmacological, cosmetic and nutritional use is obtained. The resultant product could have therapeutic and/or food properties. Toxic compounds as phenols are removed. The researchers are interested in join venture and/or manufacture agreements.
Universidad de Alcalá-OTRI posted this:Protein separation by using anionic carbosilane dendrimers.BIODEN research group (Biomedical applications of dendrimers) from the Department of Inorganic Chemistry of the University of Alcala along with the research group of Micro(sep) from the Department of Analytical Chemistry and Chemical Engineering have developed a technology based on the use of anionic dendrimers as nanoadditives in capillary electrophoresis (CE) for protein separation, more specifically for obtaining protein profiles useful in food characterization. The groups look for companies of chemical, pharmaceutical or biotechnological sector to sign research collaboration agreements or license agreements.
Fundació URV posted this:α-ketoglutarate as a predictor of morbid obesity-associated nonalcoholic fatty liver disease• Use of α-ketoglutarate as a novel biomarker of nonalcoholic fatty liver disease (NAFLD). • α-ketoglutarate analysis is a non-invasive quantitative measure of liver steatosis. • This method may reduce the need for liver biopsy, particularly in patients with metabolic risk factor. • The method could be used to design a kit to detect and quantify plasma α-ketoglutarate concentration. • Measurement of this biomarker may be useful in the assessment of NAFLD progression.
Centre Technology Transfer CITTRU posted this:New drug candidates for treatment of neuropathic pain and epilepsy.Despite the large number of available antiepileptic drugs, approximately 30% of patients fail to control seizures, and among those experiencing partial seizures (simple, complex, and secondarily generalized) the percentage is even higher at around 40%. Such a form of epilepsy is called drug resistance. One reason for the wide prevalence is the problem of insufficient efficacy of the currently available antiepileptic drugs. Also neuropathic pain in many cases is unable to control with use of currently used drugs. One of the possible reasons is that there are many mechanisms for the formation of the peripheral and central neuropathic pain, which frequently are still poorly known. Neuropathic pain is a serious clinical problem which affects up to 7 ‐ 8% of the population. Compounds included in the offer meet requirements for new, innovative drugs efficient in epilepsy and neuropathic pain cases which are still unmet medical needs (particularly drug resistant epilepsy and uncontrolled neuropathic pain – frequently of unknown etiology).
Universidad de Alicante posted this:Innovative and efficient antifungal composition for pharmacological (human &veterinary treatment), phytosanitary and cleaning (detergents) applicationsThis technology aims to help controlling resistant strains of important filamentous fungi and yeast fungi (e.g. Candida spp.) originated after prolonged treatment with currently used antifungals. The present invention provides for these purposes: a) The use of novel antifungals (COS and chitosan). b) The combined use (synergical) with existing antifungals (e.g. fluconazole) to reduce their doses. c) The use of COS and chitosan (alone or in combination with existing synergical antifungals) with an inhibitor of ARL1 gene to increase the sensitivity of fungi (including yeast) or their chitosan oligosaccharides (COS). Several experiments carried out have shown the significant synergistic effect of the combination object of the present invention (chitosan or COS, and an inhibitor of ARL1 gene or a currently used antifungal such as fluconazole) in inhibiting growth of filamentous fungi and yeast. Chitosan and COS are non-toxic for mammals, and therefore, they have a particular interest to use them as antifungal agents in some applications.
Universidad de Alcalá-OTRI posted this:Semipurified fraction of Ganoderma lucidum with antitumour activity (cytotoxic activity and apoptotic cells in murine lymphoma and human leukemia)A fraction of compounds obtained from Ganoderma lucidum has been described. This fraction is active on murine lymphoma DA-1 cells and human leukemia NB4 cells. This fraction induced DNA fragmentation, changes in cell membrane and cell death. The innovation lies on the antitumor activity, the source of such compounds (the mushroom Ganoderma lucidum grown in stablished conditions developed in our lab).
Small and Medium Enterprise
Creative Animodel posted this:In Vitro Pharmacological Assays at Creative AnimodelCreative Animodel is specialized in providing an integrated portfolio of qualified in vitro pharmacological assays to identify targets for drugs and screen drug candidates at an early stage. With standard and custom assays, we focus on offering our global clients cost-effective, high-quality and reproducible data and flexible solutions with a fast turnaround time.