RAMOT at Tel Aviv University Ltd. posted this:Harnessing inhibitory RNA based- nanoparticles for therapeutic intervention in blood cancersModulating T cells functions by down regulating specific genes using RNA interference (RNAi) holds tremendous potential in advancing targeted therapies in many immune related disorders including cancer, inflammation, autoimmunity and viral infections. Hematopoietic cells, in general, and primary T lymphocytes, in particular, are notoriously hard to transfect with small interfering RNAs (siRNAs). Herein, we describe a novel strategy to specifically deliver siRNAs to murine CD4+ T cells using targeted lipid nanoparticles (tLNPs). To increase the efficacy of siRNA delivery, these tLNPs have been formulated with several lipids designed to improve the stability and efficacy of siRNA delivery. The tLNPs were surface functionalized with anti-CD4 monoclonal antibody (mAb) to permit delivery of the siRNAs specifically to CD4+ T lymphocytes. Ex vivo, tLNPs demonstrated specificity by targeting only primary CD4+ T lymphocytes and no other cell types. Systemic intravenous administration of these particles led to efficient binding and uptake into CD4+ T lymphocytes in several anatomical sites including the spleen, inguinal lymph nodes, blood and the bone marrow. Silencing by tLNPs occur in a subset of circulating and resting CD4+ T lymphocytes. Interestingly, we show that tLNPs internalization and not endosome escape is a fundamental event that takes place as early as one hour after systemic administration that determine tLNPs efficacy. Taken together, these results suggest that tLNPs may open new avenues for the manipulation of T cell functionality and may help to establish RNAi as a therapeutic modality in leukocyte-associated diseases. Project ID : 10-2016-962
Universidad de Alcalá-OTRI posted this:Disposable electrodes based on filtered nanomaterials.A Spanish research Group from Analytical Chemistry, Physical Chemistry and Chemical Departments at University of Alcalá (Spain) has designed and developed different disposable electrodes constituted exclusively by conducted nanomaterials for analytical measurement of electroactive molecules for (bio-) sensoric in relevant areas such as health, agri-food and environmental. The group is looking for companies in the chemistry, clinical, agri-food and environmental sectors to reach licensing agreements or collaboration and commercial agreements for technical assistance.
Universidad de Alicante posted this:New process to synthesize mesoporous solids under controlThis method is unique in the market and implies a simple procedure to control the volume and size of the mesoporosity developed in POM-based salts. This is possible thanks to the pH increase in solution during the synthesis of mesoporous solids.
RAMOT at Tel Aviv University Ltd. posted this:Date Rape Drug DetectionA low cost, easy to use and utterly reliable test kit for the detection of the most widely used date rape drugs. A sensor containing a tiny amount of solvent is exposed to a beverage. If the drug is present, its chemical reaction with the solvent will cause a change in the optical transparency of the solvent. An optical signal is measured before and after addition of the beverage and the presence of very low doses is quickly detected Project ID : 3-2011-155
RAMOT at Tel Aviv University Ltd. posted this:Product Authentication using Nanoimprinting Lithography (NIL)Product Authentication using Nanoimprinting Lithography (NIL) Project ID : 3-2009-26
RAMOT at Tel Aviv University Ltd. posted this:''Smart'' Textiles integrating Peptide NanostructuresTextiles that have been modified by integrating peptide nanostructures show remarkable properties. These include the physical and chemical properties of the fabric, such as strength and fire-resistance, as well as much more advanced properties including enzymatic activities such as self-cleaning and hazardous materials-decontamination. Project ID : 3-2009-27
RAMOT at Tel Aviv University Ltd. posted this:Heavily doped semiconductor nanocrystalsDoping of semiconductors by impurity atoms enabled their widespread technological application in micro and optoelectronics. However, for strongly confined colloidal semiconductor nanocrystals, doping has proven elusive. This arises both from the synthetic challenge of how to introduce single impurities and from a lack of fundamental understanding of this heavily doped limit under strong quantum confinement. We develop a method to dope semiconductor nanocrystals with metal impurities providing control of the band gap and Fermi energy. A combination of optical measurements, scanning tunneling spectroscopy and theory revealed the emergence of a confined impurity band and band-tailing. Successful control of doping and its understanding provide n- and p-doped semiconductor nanocrystals which greatly enhance the potential application of such materials in solar cells, thin-film transistors, and optoelectronic devices. Project ID : 3-2011-179
RAMOT at Tel Aviv University Ltd. posted this:Thin Film transparent conducting nanowires for display panelsThin Film transparent conducting nanowires for display panels Project ID : 11-2012-336
RAMOT at Tel Aviv University Ltd. posted this:Self-Assembling Aromatic di-Peptide Materials for Cosmetic ApplicationsOrganic, aromatic di-peptide self-assemble into close-caged structures of tubes, spheres and hydrogels. These exhibit excellent properties such as stability, solubility, transparency and rigidness alongside the basic peptide features utilized in cosmetics. The materials can be prepared as powder or hydrogel and be easily mixed with common cosmetic foundations. In addition to these native characteristics, methods for filling and coating the structures have been developed. Cosmetically active silver and copper colloids and other active ingredients can be integrated for slow release. These additives or delivery systems can provide cosmetic compositions with improvement of wear and adhesion properties and enhancement of treatment attributes. Project ID : 3-2011-161
RAMOT at Tel Aviv University Ltd. posted this:Super Organic Tunable and White-Light Emitting Diode (OLED) by a Natural Chromophore Separation MatrixA bio-organic framework of mucin, controlling electronic interactions between two or more energetically interacting materials, is presented. The hydrophilic mucins act as a host material for introduced nano-sized hydrophobic dyes. These can be combined in any proportion to generate photo-luminescent emitters fully tunable to any visible wavelength. The technology can provide a process for efficient and low-cost production of coatings with photo-luminescent properties. Mucins are derived from a variety of bio sources, such as bovines or ovines. We have developed a proprietary method for extracting mucins from jellyfish and are able to fabricate a homogenous photo-luminescent coating capable of controlling the emitted wavelength to any RGB combination. Project ID : 3-2012-387
RAMOT at Tel Aviv University Ltd. posted this:Rhenium Nanostructures and ElectrodepositionRhenium (Re) exhibits a unique combination of properties qualifying it to be a high performance engineering material, for applications in aerospace, electronics, medical devices and fuel cells. Rhenium has the second highest melting point of all metals, the third highest Young’s modulus of elasticity and the fourth highest density. While the other refractory metals have a body centered cubic (bcc) structure, Re has a hexagonal close packed (hcp) structure. Consequently, it does not possess a ductile-to-brittle transition and, therefore, can safely be used at subzero temperatures. In addition Re has a creep-rupture strength over a wide high temperature range, up to about 2000°C. These properties imply that structures made of Re have excellent mechanical stability and rigidity, enabling the design of parts with thin sections, extremely attractive for high-temperature structural and high energy system applications. Re nanostructures are likely to exhibit remarkable advantages over other nanostructured metals. Project ID : 3-2012-389
RAMOT at Tel Aviv University Ltd. posted this:Bismuth NanoWires and Ohmic ContactsWe have developed a reproducible method to synthesize single crystalline Bismuth nanowires (BiNWs), 40nm in diameter, with embedded quantum point contacts. We have also developed methods to characterize the ZT values of individual wires, i.e., free of any averaging of ensemble measurements, and we show that our BiNWs have superior thermoelectric properties at low temperatures (77K), with ZT>3. Project ID : 11-2013-448
RAMOT at Tel Aviv University Ltd. posted this:Disk-like hybrid nanostructuresDisk-like hybrid nanostructures Project ID : 3-2013-633
RAMOT at Tel Aviv University Ltd. posted this:Carbon Nanotube Patterning for electronic applicationsCarbon Nanotube Patterning for electronic applications Project ID : 3-2013-641
RAMOT at Tel Aviv University Ltd. posted this:Logic element based on Electrically Formed Nanowire (EFN) deviceLogic element based on Electrically Formed Nanowire (EFN) device Project ID : 11-2013-734