Universidad de Alcalá-OTRI posted this:Carbosilane dendritic compounds homo and heterofunctionalizedA Spanish research group from the Department of Organic and Inorganic Chemistry of Alcala University has developed a highly branched macromolecules called dendrimers or dendrons, with carbosilane structure and functionalized on its periphery with anionic or cationic groups, providing the macromolecule a net negative or positive charge respectively. The invention also concerns the dendrimers’ procurement process and their biomedical applications, particularly as carriers of drugs or nucleic acids (such ODN, siRNA, dsRNA or DNA), or as therapeutic agents with antiviral or antibacterial activity. The group is looking for companies in the biomedical sector to reach licensing agreements, collaboration and commercial agreements with technical assistance.
IMIM Institut Recerca Hospital del Mar posted this:A TREATMENT FOR TRIPLE NEGATIVE BREAST CANCERTriple negative breast cancers are tipically associated with por prognosis, due to aggressive tumor phenotype(s), only partial response to chemoterapy and present lack of clinically established targeted therapies and respresent the focus of increasing interest at the clinical, biological and epidemiological level, as disclosed in Podo et al., Triple –negative breast cancer: Present challenges and new perspectives, Mol. Oncol., 2010, 4, 209-229. There is, thus, a particular need for new active agents suitable for breast cancer treatment, and in particular need for triple negative breast cancers.
Universidad de Alcalá-OTRI posted this:Synthesis of dendritic systems of nanoscopic size for applications in biomedicineRegarding the cationic systems developed, the principal innovative aspects are the following: - They are non viral nanoscopic synthetic molecules able to internalise nuclear material inside different cellular lines. This turns them into good candidates to be considered as non viral vectors in gene therapy processes. - They are non toxic in a concentration range adapted for the accomplishment of different biomedical studies. - They present antibacterial properties against gram + and gram- bacteria - They are able of interacting, in a electrostatic way, with anionic drugs which turns them into drug delivery systems. - They present a hydrophobic carbosilane skeleton that allows the molecules to cross the cellular membranes with major facility. - They are soluble in water. Regarding the anionic systems developed, the principal innovative aspects are the following: - They have an important antiviral capacity - They are able to inhibit the infection for HIV - They have antiinflammatory capacity - They are good candidates for the production of a microbicide gel of topic use that prevents the infection of the virus across sexual transmission.
Technology Transfer Office
RAMOT at Tel Aviv University Ltd. posted this:Harnessing inhibitory RNA based- nanoparticles for therapeutic intervention in blood cancersModulating T cells functions by down regulating specific genes using RNA interference (RNAi) holds tremendous potential in advancing targeted therapies in many immune related disorders including cancer, inflammation, autoimmunity and viral infections. Hematopoietic cells, in general, and primary T lymphocytes, in particular, are notoriously hard to transfect with small interfering RNAs (siRNAs). Herein, we describe a novel strategy to specifically deliver siRNAs to murine CD4+ T cells using targeted lipid nanoparticles (tLNPs). To increase the efficacy of siRNA delivery, these tLNPs have been formulated with several lipids designed to improve the stability and efficacy of siRNA delivery. The tLNPs were surface functionalized with anti-CD4 monoclonal antibody (mAb) to permit delivery of the siRNAs specifically to CD4+ T lymphocytes. Ex vivo, tLNPs demonstrated specificity by targeting only primary CD4+ T lymphocytes and no other cell types. Systemic intravenous administration of these particles led to efficient binding and uptake into CD4+ T lymphocytes in several anatomical sites including the spleen, inguinal lymph nodes, blood and the bone marrow. Silencing by tLNPs occur in a subset of circulating and resting CD4+ T lymphocytes. Interestingly, we show that tLNPs internalization and not endosome escape is a fundamental event that takes place as early as one hour after systemic administration that determine tLNPs efficacy. Taken together, these results suggest that tLNPs may open new avenues for the manipulation of T cell functionality and may help to establish RNAi as a therapeutic modality in leukocyte-associated diseases. Project ID : 10-2016-962
Research & Technology Organization
UNIVERSIDAD DE ALICANTE posted this:Sustainable production of biofuel (bioethanol) from shellfish wasteThe research group of Plant Pathology at the University of Alicante has developed a new process by using fungi to produce biofuel (bioethanol) and fungal biomass for agrobiotech use from shellfish waste. It is a sustainable alternative to agroforestry crops currently used. The current technology stands out because it uses chitosan as the sole source of nutrients, and produces bioethanol in profitable, sustainable and environmentally friendly manner. The research group is looking for companies or investors partners interested in acquiring this technology for commercial exploitation.
Barcelona Skin Genomic posted this:Recommendation of optimal combinations of natural active compounds to treat disease using a databaseBarcelona Skin Genomic (BSG) is developing a database that compiles information about the effects of different natural active compounds or plant extracts (more than 2500) on gene expression, on the levels of expression of interleukins and other molecules (more than 3400) and on treatment of different diseases (677). This database collects information from more than 5000 scientific articles, integrated by biologists and experts in life sciences and is updated on a monthly basis.
Technology Transfer Office
UNIVERSIDAD DE BURGOS posted this:Compounds capable of facilitating the transmembrane anion transport for the treatment of Cystic FibrosisThe field of the invention is related to compounds containing a triazole-dipyrromethene core which facilitate the anion transport through lipid membranes. These molecules are capable of mimicking the function of transmembrane proteins and thus replacing their function at cellular level. These compounds are particular useful for the treatment of diseases related to malfunction of natural anion transport mechanisms such as Cystic Fibrosis.
Fundació URV posted this:Catalytic wastewater treatment for organic matter removalThe catalytic technology allows you to remove high concentrations of COD (40.000-200.000ppm) at atmospheric pressure. All kind of organic compunds are removed (biodegradable and non biodegradable ones). The catalyst life is around 2-3 years. It is an exothermic process, so the energy needed for the process is just for the start up. The process works at 250-350ºC.
Centre Technology Transfer CITTRU posted this:Method of isolation and purification of xanthophylls from diatom cultureXanthophylls, with their antioxidant, anticancer, anti-inflammatory and neuroprotective properties, found important applications in food and nutrition, cosmetic and environmental industries, as well as pharmacy and medicine. Diadinoxanthin (Ddx) and diatoxanthin (Dtx) are two pigments that belong to xanthophylls family. The availability of Ddx and Dtx on the market is low and up to date limited as they are sold exclusively in small quantities at extremely high prices to be used as HPLC calibration standards. The solution of the above mentioned problems is the 5-step method for the isolation and purification of Ddx and Dtx developed at the Jagiellonian University..
Centre Technology Transfer CITTRU posted this:Staphylococcus pseudintermedius & bacteriocins – various applicationsThe subject of the present offer is new bacterial strain Staphylococcus pseudintermedius Sp222, isolated from dog pathologic dermal lesions. The offer includes also peptide and protein bacteriocins produced by S. pseudintermedius Sp222. These bacteriocins exhibit a broad spectrum of biological activities: - bacteriocin BacSp222 is able to kill a variety of Gram+ bacteria strains, including the methicillin resistant S. aureus (MRSA) strain. It is also cytotoxic towards selected eukaryotic cells and is resistant to action of proteolytic enzymes (either eukaryotic or prokaryotic) as well as to high temperature. The biological activity of BacSp222 is sustained even after limited fragmentation of its molecule by chemical reagents; - lysostaphin Sp222 has an ability to effectively lyse (and, in consequence, to kill) the cells of Gram+ bacteria.
Centre Technology Transfer CITTRU posted this:Monoclonal antibody Miraculum for serological diagnostic in vitroNew IgG antibody suitable for specific agglutination of erythrocytes, particulary for blood typing. The unique IgG3 antibody Miraculum may be a valuable, high-quality, next generation blood typing reagent with extended shelf life. It does not lose its property after freezing. Its production is very efficient and can be more profitable compared to currently used IgM-class antibody. The invention consists in conversion of any non-agglutinating monoclonal antibody that recognizes an antigen on the surface of human erythrocytes into agglutinating molecule. The antibodies obtained in this way can be much more useful than IgM antibodies, which are currently used in agglutination assays.
Fundació URV posted this:NEW PROCEDURE FOR OBTAINING MONOLAYERS OF FUNCTIONALIZED NANOPARTICLESThis new procedure (not described in the bibliography) allows the manufacture of monolayers of metal nanoparticles linked by molecules of organic compounds. As you can see in Specifications, this procedure consists in two successive processes. One of the main advantages of this technology is the minimization of impurities in the functionalized monolayer compared to commonly used techniques. Besides, the manufacture of Schotty diode with this new procedure has been shown for the first time. In the same line, this procedure allows the use of monolayers of metal nanoparticles for metabolite detection. These are two unique and differents aspects of this technology in relation to other known used techniques.
Universidad de Alcalá-OTRI posted this:Procedure for obtaining peptides with antioxidant and antihypertensive properties from olive seeds.A research group from the Analytical Chemistry Department at Alcalá University has developed a procedure from which it is possible to obtain peptides with antihypertensive and antioxidant capacity of isolated proteins from olive seed by enzymatic digestion. The method consists of the protein extraction from the olive seeds using a previously developed process, and digest the extracted proteins with Thermolysin enzyme, allowing to obtain peptides with antihypertensive capacity in vitro, or with Alcalase enzyme leading to obtain a peptide extract with antioxidant properties. The group seeks to establish commercial , licensing or collaboration agreements with companies of the food and pharmaceutical sectors interested in both the use strategy of this waste material (olive pits), as in the use of the found bioactive peptides.