Yissum - Research Development Company of the Hebrew University posted this:Medical Imaging Method and Systemmethod and system for analysis of color change in images in the human body. The method is used for diagnosis of such disorders that changes in color of tissues occeurs. Keywords: image processing, algorithm, dental care With Hadasit Project ID : 7-2006-854
Yissum - Research Development Company of the Hebrew University posted this:Novel Approach to Improve Production of Secondary Metabolites in YeastNovel Approach to Improve Production of Secondary Metabolites in Yeast Project ID : 8-2012-2767
Yissum - Research Development Company of the Hebrew University posted this:Non-Viral Delivery Method for Gene TherapyA novel technology of non-viral delivery of genetic material (genes, pDNA, antisense, oligonucleotides etc., termed: gene) has been developed. The gene is encapsulated in biocompatible and biodegradable polymeric nanoparticles that provide efficient transfection, controlled-release and gene therapy. Keywords: Oligonucleotides, gene therapy Project ID : 12-2006-172
UATEC - Unidade de Transferência de Tecnologia posted this:DNA Barcodes – DNA authentication mark (traceability and identification of food products)The present invention consists on the development and application of "molecular tags" or “molecular barcoded labels”, of easy synthesis and production in large quantities. These labels are of simple application, invisible to the naked eye and of rapid detection using low cost equipments and reagents typically used for molecular biology. Basically, the labels consist of chimerical molecules of deoxyribonucleic acid (DNA) and the detection and read of these molecules do not depend on sequencing approaches. The information in these labels can be accessed in a similar way as it is done for most common barcoded systems.
Fundació URV posted this:α-ketoglutarate as a predictor of morbid obesity-associated nonalcoholic fatty liver disease• Use of α-ketoglutarate as a novel biomarker of nonalcoholic fatty liver disease (NAFLD). • α-ketoglutarate analysis is a non-invasive quantitative measure of liver steatosis. • This method may reduce the need for liver biopsy, particularly in patients with metabolic risk factor. • The method could be used to design a kit to detect and quantify plasma α-ketoglutarate concentration. • Measurement of this biomarker may be useful in the assessment of NAFLD progression.
Universitat de València posted this:Test Kit for anionic surfactant in waterThe most remarkable advantages provided by this technology are: o Simplicity and versatility of the kit, which allows carrying out a high throughput screening or in situ analysis with very short analysis times. o Low analysis cost, since dyes, organic solvents that generate residues and instrumental equipment are not used. o High sensitivity of the method, that detect anionic surfactant concentration lower than the maximum residue limit established in most of the environmental legislation.
Universitat de València posted this:Passive sampler for monitoring atmospheric pollutants (VERAM)The most remarkable advantages provided by this technology are: o Versatility, it is possible to sample a big number of pollutants using a single device containing a combination of solid phases. o Greater adsorption capacity and high analytic sensitivity with smaller sampling time than market available devices. o Rapidity and low cost of pollutant analysis. Thermal desorption and head space injection minimize sample handling, do not require the use of solvents and reduce the time of analysis. o Cheap passive samplers with a fast and simple fabrication procedure. o VERAM permits a multidirectional sampling differing from radial or one-way sampling devices with encapsulated solid phases.
Universitat de València posted this:New method for the synthesis of inert metallic nanoparticlesThe most remarkable advantages provided by this technology are: • Rapidity of the metallic nanoparticle synthetic method, as it consists of only one step. • Efficiency, since size, shape and concentration of nanoparticles are controlled, as well as, their production in organic or inorganic soluble solution. • Reduced production costs, as high temperatures are required by other alternative laser ablation methods.
Universitat de València posted this:Magnetic In-Tube Solid Phase MicroextractionThe device has the following advantages over existing equipment: Allows quantitative extraction efficiency, solving one of the main drawbacks of IT-SPME systems Broadens applicability of IT-SPME thus making available its advantages (automation, precision) to specific analyses that require high sensitivity of analytes estimation.
Centre Technology Transfer CITTRU posted this:New drug candidates for treatment of neuropathic pain and epilepsy.Despite the large number of available antiepileptic drugs, approximately 30% of patients fail to control seizures, and among those experiencing partial seizures (simple, complex, and secondarily generalized) the percentage is even higher at around 40%. Such a form of epilepsy is called drug resistance. One reason for the wide prevalence is the problem of insufficient efficacy of the currently available antiepileptic drugs. Also neuropathic pain in many cases is unable to control with use of currently used drugs. One of the possible reasons is that there are many mechanisms for the formation of the peripheral and central neuropathic pain, which frequently are still poorly known. Neuropathic pain is a serious clinical problem which affects up to 7 ‐ 8% of the population. Compounds included in the offer meet requirements for new, innovative drugs efficient in epilepsy and neuropathic pain cases which are still unmet medical needs (particularly drug resistant epilepsy and uncontrolled neuropathic pain – frequently of unknown etiology).
Universitat de València posted this:Passive sensor for in situ detection of amines in atmospheres Simplicity and ease of use: it is a passive colorimetric sensor that does not require any kind of pretreatment or power supply or external instrument. Low cost: simple fabrication process without high costs Low detection limits: suitable for use in real atmospheres, of the order of 3 mg/m3. Quantitative detection: direct quantitative detection can be carried out by diffuse reflectance of the sensors. Stability: against a wide range of temperatures and to humidity and solar radiation. Reversion resistance.
Universitat de València posted this:Sample collection devices of atmospheric pollutants with high performanceThe main advantages provided by the invention are: Simplicity and reproducibility in the synthesis of the new compound, due to one step synthesis process with simultaneous addition of all reagents. It isn’t necessary the removal of CDs, and it hasn’t intermediate compounds between silica and CDs. It allows the access to VOCs without any post-treatment. Adaptability of the compound to the requirements of each sample collection devices, adjusting the grain size by milling and using appropriate sieves. Procedure cleaner, safer and more economic, since it reduces the generation of toxic waste and the risk of contamination of workers. Reduce analysis time since desorption of pollutants retained in the sample collection devices can be thermal. Retention of pollutants is more independent of environmental conditions than commercial devices.
Universitat de València posted this:Environmentally friendly colorimetric sensors for detecting hydrogen cyanide (HCN)The main advantages provided by the this colorimetric sensor are: - Detection Limits: The direct reaction between the sensor and the HCN leads to a marked color change with detection limits below 1 ppm. - Selectivity: in the presence of other gases such as CO, HCl, NH3, H2S, at concentrations up to 50 ppm - Environmentally friendly: no heavy metals used. - Reversibility: The reaction is reversible by irradiation with UV light so it can be reused in successive cycles - Minimizing false positives: Regeneration by UV radiation occurs only if the sensor reacted with HCN.
Centre Technology Transfer CITTRU posted this:A new PCR method for detection of bacteria and fungi in biological sample.In the treatment of bloodstream infections the most important and difficult problem of determining the effectiveness of treatment and, consequently, the cost and time of hospitalization is the effective diagnosis of factors causing a systemic inflammatory response in sepsis. The material subjected to diagnostic testing is blood taken from a patient showing clinical signs of sepsis. The greatest difficulty is the very small amount of microorganisms being responsible for the infection in the blood, or they are only periodically seeded into the blood. Currently, the standard diagnostic blood cultures are performed with specialized broth media, preferably in automatic culture systems. A weakness of these methods are time consumption (until a result of the study) and low sensitivity, which causes that in only 15-20% of the culture it is possible to achieve the growth of microorganisms. The situation is further complicated by the fact that patients undergo antibiotic treatment before a blood sample is taken for culture. In this case blood cultures are very difficult due to the fact that they contain antibiotics which inhibit the growth of microorganisms. The molecular biology techniques, such as PCR or hybridization, belong to diagnostic methods that provide reliable, accurate and fast diagnosis of bloodstream infections. The sensitivity of molecular methods is much higher than the sensitivity of the culture method. However, currently available systems enable the detection of several particular species of microorganisms or every possible gene in theory, but on the other hand they require sequencing of PCR product, which in turn increases the cost and time for the result. The proposed new PCR method allows simultaneous DNA detection of the entire panel of bacterial and fungal microorganisms, with the differentiation of Gram-negative bacteria, Gram-positive bacteria, yeasts fungi and molds in a sample of biological material (including patient's spittle or blood). There is the possibility of using the detection method only for bacteria or fungi, or for the simultaneous detection of both fungi and bacteria, which reduces the cost of testing. There is also the opportunity to identify a specific species of microorganism after sequencing of the PCR product.
Centre Technology Transfer CITTRU posted this:A diagnostic test of Streptococcus agalactiae infections in pregnant women.Rapid diagnosis of infections caused by GBS guarantees the immediate implementation of antibiotic therapy. However, there are currently no diagnostic tests that allow confirmation of infections caused by S. agalactiae. Previous diagnostic methods traditionally used in carriage of S. agalactiae are based on method of cultivation (the so-called „gold standard”), which has a low sensitivity and a long time (up to several days) to wait for result. The another approach are metods of molecular biology, including methods for real-time PCR, which allow to obtain a result in a short time. However they are very expensive and they also require the use of special equipment. The proposed new test uses four highly immunoreactive amino acid sequences belonging to proteins of S. agalactiae. It shows a high sensitivity and specificity. The results of this test are obtained in a short time (up to 8 hours). One of the most important features of new test is the lack of special equipment to carry out a new diagnostic test. The proposed test may confirm the Streptococcus agalactiae infections in pregnant women. There is the possibility to extend the application of diagnostic test for detection of infections based on GBS etiology in other patient groups (e.g. infants, outpatients and hospital patients) and using other clinical materials (plasma, cerebrospinal fluid).