The invention herein disclosed relates to a new cationic steroid showing antibacterial, antifungal, and antibiofilm activities, including when immobilized in coating polymers.
The present invention provides an amphiphilic small-molecule with bactericidal and fungicidal activity. The compound is synthesized in scalable conditions from readily available and low-cost building blocks. The molecule shows significant biocidal activity against multidrug-resistant bacteria, including the ESKAPE pathogens, and fungi. Notably, the compound acts synergistically with amphotericin B and fluconazole against the reference Candida albicans strain. Significant dose-dependent disruption of bacterial membranes is observed upon treatment with the new cationic steroid. Polymeric coatings containing up to 1.5 % w/v cationic steroid sustain effective reduction of the formation of E. coli biofilms in ureteral stents, in relevant hydrodynamic conditions.
Current development status
Experimental technologies
Applications
Antimicrobial therapeutics against veterinary and/or human pathogens
Antimicrobial coating or disinfection of medical devices
Mild detergent for emulsification of lipids
Aquaculture feed formulations for infectious disease control
Desired business relationship
Technology selling
Patent licensing
Technology development
Adaptation of technology to other markets
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