NEW CATIONIC STEROID WITH ANTIMICROBIAL PROPERTIES

  • Maria from University of Porto
  • From Portugal
  • Responsive
  • Patents for licensing

Summary of the technology

The invention herein disclosed relates to a new cationic steroid showing antibacterial, antifungal, and antibiofilm activities, including when immobilized in coating polymers.

University of Porto

Details of the Technology Offer

The present invention provides an amphiphilic small-molecule with bactericidal and fungicidal activity. The compound is synthesized in scalable conditions from readily available and low-cost building blocks. The molecule shows significant biocidal activity against multidrug-resistant bacteria, including the ESKAPE pathogens, and fungi. Notably, the compound acts synergistically with amphotericin B and fluconazole against the reference Candida albicans strain. Significant dose-dependent disruption of bacterial membranes is observed upon treatment with the new cationic steroid. Polymeric coatings containing up to 1.5 % w/v cationic steroid sustain effective reduction of the formation of E. coli biofilms in ureteral stents, in relevant hydrodynamic conditions.

Current development status

Experimental technologies

Applications

Antimicrobial therapeutics against veterinary and/or human pathogens

Antimicrobial coating or disinfection of medical devices

Mild detergent for emulsification of lipids

Aquaculture feed formulations for infectious disease control

Desired business relationship

Technology selling

Patent licensing

Technology development

Adaptation of technology to other markets

Intellectual property status

  • Patent already applied for
  • Patent application number :Provisional patent application No.17633

Related Keywords

  • Materials Technology
  • Industrial Technologies
  • Clean Industrial Technologies
  • Pharmaceutics
  • biofilm
  • antibiotic
  • antimicotic
  • catheter
  • surfactant

About University of Porto

U.Porto Innovation focuses its activities on research at the University, entrepreneurship within the academic community and U.Porto’s growing connections with industry.

Maria Antónia Nunes

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