A Novel Therapeutic Approach Targeting Coronavirus Replication-Essential RNAs by Oligonucleotides
Project ID : 47-2020-10912
The research team plans to develop a drug to inhibit human SARS-CoV-2 replication. They will use comparative genomics to detect conserved regions within the coronavirus family, and within human CoV-19 population, in order to identify essential genes that can be targeted to inhibit the virus replication.
The drug will be a relevant allele-specific oligonucleotide (ASOs), to be delivered into the lung epithelial cells. Following delivery into lung cells, the ASOs will bind the virus’ essential mRNAs, activate RNAse and induce degradation of these mRNAs, and inhibit replication of the virus in the cells.
Project manager
Mel Larrosa
VP Business Development Healthcare
Project researchers
Rotem Karni
HUJI, School of Medicine - IMRIC
Biochemistry and Molecular Biology
Yuval Tabach
HUJI, School of Medicine - IMRIC
Developmental Biology and Cancer Research
Alexander Rouvinski
HUJI, School of Medicine - IMRIC
Microbiology and Molecular Genetics
Yissum - Research Development Company of the Hebrew University
Technology Transfer Office from Israel
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Founded in 1964 to protect and commercialize the Hebrew University’s intellectual property. Ranked among the top technology transfer companies, Yissum has registered over 8,900 patents covering 2,500 inventions; has licensed out 800 technologies and has spun-off 90 companies. Products that are based on Hebrew University technologies and were commercialized by Yissum generate today over $2 Billion in annual sales.
Create your free account to connect with Yissum - Research Development Company of the Hebrew University and thousands of other innovative organizations and professionals worldwide
Send a request for information
to Yissum - Research Development Company of the Hebrew University
Technology Offers on Innoget are directly posted
and managed by its members as well as evaluation of requests for information. Innoget is the trusted open innovation and science network aimed at directly connect industry needs with professionals online.
Need help requesting additional information or have questions regarding this Technology Offer?
Contact Innoget support
