Yissum - Research Development Company of the Hebrew University

Developing Quicker and Simpler Testing Method for COVID19

Posted by Yissum - Research Development Company of the Hebrew UniversityResponsive · Innovative Products and Technologies · Israel

Summary of the technology

Developing Quicker and Simpler Testing Method for COVID19
Project ID : 46-2020-10903

Yissum - Research Development Company of the Hebrew University

Description of the technology

Dr. Eitan Lerner’s lab has diverted its expertise to developing more efficient testing for COVID19. Diagnosis of COVID19 is currently performed via RNA extraction & RT-PCR, which is labor-intensive, time consuming, and requires use of existing kits. While the viral RNA genome does include specific sequences, it can (and has been reported to) introduce contamination to surfaces, which can lead to false positive identifications.

An alternative mode of identification involves high-sensitivity fluorescent detection of the specific factors in the virus, without amplification. Using this method will save time, labor and (bio)chemical resources to produce highly specific results, even when the targets are at low concentrations.

In order to do this, Dr. Lerner’s lab is using confocal-based fluorescent detection of one viral particle at a time. It is currently developing a bio-identification of intact viral particles based on the coincident detection of it based on its size and on its specific interaction with the Angiotensin-converting enzyme 2 (ACE2).

Dr. Lerner’s team is currently performing proof-of-concept measurements, and the next step is to prepare the involved proteins/probes components and to test them against model systems embedded with the COVID19 spike proteins. The goal would be to test these modalities against pseudovirions, or other safe(r) modes of the virus particle.

Project manager

Mel Larrosa
VP Business Development Healthcare

Project researchers

Eitan Lerner
HUJI, Faculty of Science
The Alexander Silberman Institute for Life Sciences

Related keywords

  • In vitro Testing, Trials Technology
  • Virus, Virology / Antibiotics / Bacteriology
  • Biological Sciences
  • Infectious Diseases
  • Diagnostics, Diagnosis
  • In-vitro diagnostics
  • Diagnostic equipment
  • covid-19

About Yissum - Research Development Company of the Hebrew University

Technology Transfer Office from Israel

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Founded in 1964 to protect and commercialize the Hebrew University’s intellectual property. Ranked among the top technology transfer companies, Yissum has registered over 8,900 patents covering 2,500 inventions; has licensed out 800 technologies and has spun-off 90 companies. Products that are based on Hebrew University technologies and were commercialized by Yissum generate today over $2 Billion in annual sales.

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