Yissum - Research Development Company of the Hebrew University

Deciphering the Virus-Host Tango: Understanding network of interactions through evolution, structure, dynamics, and computational design

Posted by Yissum - Research Development Company of the Hebrew UniversityResponsive · Innovative Products and Technologies · Israel

Summary of the technology

Their title: Deciphering the Virus-Tango:
Project ID : 47-2020-10875

Description of the technology

We compare the interaction between the human ACE2 receptor and the SARS-CoV-2 spike protein with that of other pathogenic coronaviruses using molecular dynamics simulations.

Molecular dynamics simulations reveal a temporal dimension of coronaviruses interactions with the host receptor. The main highlights are:

  • Accelerated evolution in the ACE2 binding interface of human pathogenic coronaviruses
  • Comparable binding affinities of SARS-CoV-2 and SARS-CoV are reached by exploiting very different binding strategy with respect to dynamic, contacts, and interface area
  • The design of future therapeutics should consider dynamics in addition to static structural models.

Using our methodology, we will identify and classify protein-protein interactions, understand the sub-steps in viral infection mechanism, and suggest the most successful therapeutic strategies.

Project manager

Mel Larrosa
VP Business Development Healthcare

Project researchers

Michal Linial
HUJI, Faculty of Science
The Alexander Silberman Institute for Life Sciences

Dina Schneidman
HUJI, School of Computer Science and Engineering

Related keywords

  • Biological Sciences
  • Medicine, Human Health
  • Virus, Virology / Antibiotics / Bacteriology
  • E-Health
  • Infectious Diseases
  • Covid-19
  • covid-19

About Yissum - Research Development Company of the Hebrew University

Technology Transfer Office from Israel

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Founded in 1964 to protect and commercialize the Hebrew University’s intellectual property. Ranked among the top technology transfer companies, Yissum has registered over 8,900 patents covering 2,500 inventions; has licensed out 800 technologies and has spun-off 90 companies. Products that are based on Hebrew University technologies and were commercialized by Yissum generate today over $2 Billion in annual sales.

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