Deciphering the Virus-Host Tango: Understanding network of interactions through evolution, structure, dynamics, and computational design

Summary of the technology

Their title: Deciphering the Virus-Tango:
Project ID : 47-2020-10875

Details of the Technology Offer

We compare the interaction between the human ACE2 receptor and the SARS-CoV-2 spike protein with that of other pathogenic coronaviruses using molecular dynamics simulations.

Molecular dynamics simulations reveal a temporal dimension of coronaviruses interactions with the host receptor. The main highlights are:

  • Accelerated evolution in the ACE2 binding interface of human pathogenic coronaviruses
  • Comparable binding affinities of SARS-CoV-2 and SARS-CoV are reached by exploiting very different binding strategy with respect to dynamic, contacts, and interface area
  • The design of future therapeutics should consider dynamics in addition to static structural models.

Using our methodology, we will identify and classify protein-protein interactions, understand the sub-steps in viral infection mechanism, and suggest the most successful therapeutic strategies.

Project manager

Mel Larrosa
VP Business Development Healthcare

Project researchers

Michal Linial
HUJI, Faculty of Science
The Alexander Silberman Institute for Life Sciences

Dina Schneidman
HUJI, School of Computer Science and Engineering

Related Keywords

  • Biological Sciences
  • Medicine, Human Health
  • Virus, Virology / Antibiotics / Bacteriology
  • E-Health
  • Infectious Diseases
  • Covid-19
  • covid-19

About Yissum - Research Development Company of the Hebrew University

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Founded in 1964 to protect and commercialize the Hebrew University’s intellectual property. Ranked among the top technology transfer companies, Yissum has registered over 8,900 patents covering 2,500 inventions; has licensed out 800 technologies and has spun-off 90 companies. Products that are based on Hebrew University technologies and were commercialized by Yissum generate today over $2 Billion in annual sales.

Yissum - Research Development Company of the Hebrew University

Never miss an update from Yissum - Research Development Company of the Hebrew University

Create your free account to connect with Yissum - Research Development Company of the Hebrew University and thousands of other innovative organizations and professionals worldwide

Yissum - Research Development Company of the Hebrew University

Send a request for information
to Yissum - Research Development Company of the Hebrew University

About Technology Offers

Technology Offers on Innoget are directly posted
and managed by its members as well as evaluation of requests for information. Innoget is the trusted open innovation and science network aimed at directly connect industry needs with professionals online.

Help

Need help requesting additional information or have questions regarding this Technology Offer?
Contact Innoget support