Yissum - Research Development Company of the Hebrew University

Ultra-Low Dose Radiation for Repeat CT Scanning

Posted by Yissum - Research Development Company of the Hebrew UniversityResponsive · Innovative Products and Technologies · Israel

Summary of the technology

Ultra-Low Dose Radiation for Repeat CT Scanning
Project ID : 46-2019-10755

Description of the technology


Life Sciences and Biotechnology


Ultra low dose radiation CT scanning, repeat CT scanning

Current development stage

For medical device: TRL3 - Hypothesis testing and initial POC is demonstrated in limited number of in-vitro models


Computer Tomography (CT) studies are pervasive and play a central role in all aspects of patient care, allowing for diagnosis, planning procedures, intra-procedural monitoring, and post-procedural evaluation. The main disadvantage of CT imaging is that it exposes the patient to a substantial amount of ionizing radiation that may be harmful to the patient. This problem is exacerbated for repeat CT scanning, in which a patient is scanned one or more times after a baseline scan has been acquired. Repeat scanning is very common in many clinical situations, e.g. multi-phase scanning, follow-up scanning in oncology, intraoperative monitoring and more. Much research has been recently devoted to developing methods for achieving clinically viable procedures with the lowest possible radiation dose.

Our Innovation

We have developed a unique method for dose optimization in repeat CT scanning. The main advantages of the method are:

  • It enables a ten-fold radiation dose reduction with very little image quality loss in the ROI.
  • It accounts for patient body motions and organs deformations.
  • It can be used offline for diagnosis and online for interventional CT.


This technology is expected to provide a competitive edge to manufacturers of CT scanners and to companies developing ultra-low dose X-ray scanning hardware and software. The new method may directly benefit patients who require multiple scans of the same body region and/or are periodically evaluated with CT scanfor cancer development.

Project manager

Mel Larrosa
VP Business Development Healthcare

Project researchers

Leo Joskowicz
HUJI, School of Computer Science and Engineering
Computer Science

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About Yissum - Research Development Company of the Hebrew University

Technology Transfer Office from Israel

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Founded in 1964 to protect and commercialize the Hebrew University’s intellectual property. Ranked among the top technology transfer companies, Yissum has registered over 8,900 patents covering 2,500 inventions; has licensed out 800 technologies and has spun-off 90 companies. Products that are based on Hebrew University technologies and were commercialized by Yissum generate today over $2 Billion in annual sales.

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