Summary of the technology
HAPPY is a microfluidic chip for high throughput drug screening in the area of longevity. Unlike all other methods, it is self-sufficient and does not require specialized equipment apart from the chip itself. It reduces manual workload by more than 92 %, and thus, enables pharmaceutical companies and drug developers to screen large collections of compounds for their lifespan extending properties. In addition, it enables the use of the lifespan properties of industrial production strains as optimization parameters.
Description of the technology
Faster and reliable solution compared to existing RLS determination solutions. Single-use HAPPY-chip allows to perform high numbers of experiments in parallel and does not require expensive additional equipment or further microfluidic expertise. Thus, HAPPY chips can be used in every yeast lab in the world. The technique allows designing of stand-alone centrifugal devices, which could be operated by using commercial bench centrifuges.
IP AND AREAS OF APPLICATION
The technique allows designing of stand-alone centrifugal devices, which could be operated by using commercial bench centrifuges and it’s applicable in the high-throughput screening of the lifespan extending properties of drugs (e.g. drug repurposing) and natural products (e.g. cosmetic supplements) but also for the optimization of industrial productions strains, as the productivity of a yeast cell depends on its aging properties.
Intellectual property status
Patent number: PCT/EP2019/072988: Microfluidic systems for yeast aging analysis Priority date: 28-Aug-2018
University of Luxembourg
Research & Technology Organization