Summary of the technology
This Novel Microfluidic circuit has been developed in MicroTechLab of the Mechanical Engineering Department of UPC. Currently, partners to further develop the system and/or to establish commercial agreements along with technical cooperation are sought.
Nowadays, there is a growing need for lab‐on‐chip devices especially in clinical analysis and diagnos cs. First step in most blood assays is plasma extrac on from whole blood.
Compared to tradi onal centrifuga on processes ”lab‐on‐a‐chip” devices minimize the manipula on errors, reduce the me from blood collec on to the test and provide faster and yet less expensive and comprehensive results since the amount of sample and reagents are dras cally reduced. Although many researchers have developed plasma separa on from whole blood u lizing diﬀerent techniques, the volume of extracted plasma and the separa on me are the two main barriers to implement the current commercial test on microfluidic pla orms.
This patent presents a novel high throughput blood plasma separa on microfluidic chip which has been designed and fabricated to be used as first step in a point‐of‐care Device to maximize the amount of plasma extracted from a single blood droplet. Hydrodynamic behavior of red blood cells in a Polydimethylsiloxane (PDMS) constric on channel, plasma extrac on using a symmetric cross flow filtra on MIMP (Microchannel Integrated Micro‐ Pillars) channel together with electrokine c techniques are used to maximize the amount of extracted plasma and minimize the me required for a complete separa on.
Current stage of development
Prototypes have been developed and tested. An industrial manufacturing process is defined.
Applications and Target Market
Clinical Laboratories and In Vitro Diagnostic Industry
The presented microdevice has several advantages:
Maximized amount of extracted plasma (aprox. 15% initial volume)
Outstanding purity (aprox. 99%)
Minimized required time (less than 3 minutes)
Multiple assay integration in a single microfluidic chip
Intellectual property status
Technology available for licensing with technical cooperation Patent Status US and EP patent application
Universitat Politècnica de Catalunya - UPC
Technology Transfer Office