Universitat Politècnica de Catalunya - UPC

SELF DRIVEN MICROFLUIDIC FILTER FOR SEPERATING LIQUID FROM A LIQUID INCLUDING DEFORMABLE PARTICLES (I.E. PLASMA FROM BLOOD)

Posted by Universitat Politècnica de Catalunya - UPCResponsive · Patents for licensing · Spain

Summary of the technology

This Novel Microfluidic circuit has been developed in MicroTechLab of the Mechanical Engineering Department of UPC. Currently, partners to further develop the system and/or to establish commercial agreements along with technical cooperation are sought.

Universitat Politècnica de Catalunya - UPC
Universitat Politècnica de Catalunya - UPC

The Challenge


Nowadays, there is a growing need for lab‐on‐chip devices especially in clinical analysis and diagnos cs. First step in most blood assays is plasma extrac on from whole blood.
Compared to tradi onal centrifuga on processes ”lab‐on‐a‐chip” devices minimize the manipula on errors, reduce the me from blood collec on to the test and provide faster and yet less expensive and comprehensive results since the amount of sample and reagents are dras cally reduced. Although many researchers have developed plasma separa on from whole blood u lizing different techniques, the volume of extracted plasma and the separa on me are the two main barriers to implement the current commercial test on microfluidic pla orms.

The Technology


This patent presents a novel high throughput blood plasma separa on microfluidic chip which has been designed and fabricated to be used as first step in a point‐of‐care Device to maximize the amount of plasma extracted from a single blood droplet. Hydrodynamic behavior of red blood cells in a Polydimethylsiloxane (PDMS) constric on channel, plasma extrac on using a symmetric cross flow filtra on MIMP (Microchannel Integrated Micro‐ Pillars) channel together with electrokine c techniques are used to maximize the amount of extracted plasma and minimize the me required for a complete separa on.

Current stage of development


Prototypes have been developed and tested. An industrial manufacturing process is defined.

Applications and Target Market


Clinical Laboratories and In Vitro Diagnostic Industry

Innovative advantages


The presented microdevice has several advantages:
Maximized amount of extracted plasma (aprox. 15% initial volume)
Outstanding purity (aprox. 99%)
Minimized required time (less than 3 minutes)
Multiple assay integration in a single microfluidic chip

Intellectual property status

Granted Patent
-
Technology available for licensing with technical cooperation Patent Status US and EP patent application

Technology Owner

Universitat Politècnica de Catalunya - UPC

Technology Transfer Office

Related keywords

  • Electronics, IT and Telecomms
  • In vitro Testing, Trials Technology
  • Clinical Research, Trials
  • Diagnostics, Diagnosis
  • In-vitro diagnostics
  • In vitro Testing, Trials Market
  • Clinical Medicine
  • Laboratory equipment
  • Diagnostic
  • Diagnostic services
  • Other diagnostic

About Universitat Politècnica de Catalunya - UPC

Technology Transfer Office from Spain

The Universitat Politècnica de Catalunya - BarcelonaTech is a public institution dedicated to higher education and research in the fields of engineering, architecture and science, which contributes its knowledge and expertise in order to increase scientific output, transfer its results to society and provide a network of scientific and technical state-of-the-art facilities and technology valorization services that place us at the leading edge of innovation and economic development.

The UPC has established itself as a driver of innovation and is the technology partner of choice for companies and organizations with which it develops projects and builds partnerships. A role borne out by the numerous agreements and research projects that have been set in motion by groups, organizations and laboratories; the creation of new technology-based companies; the generation and exploitation of patents, and the scientific and technical services UPC makes available to its environment in order to generate progress and employment.

The Technology Transfer Office (SGI) is responsible of Designing, coordinating and implementing research valorisation strategies, carrying out the protection policy of the research results, marketing these results through license contracts and designing and setting up the University's enterprise creation model in order to transfer the results of the research to the market, protect and commercialize these results, promote the culture of entrepreneurship and innovation, and create technology-based companies within the UPC environment.

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