Biochemize SL

Production of cis-3-hexenol and trans-4-hexenal from linseed oil

Posted by jaume from Biochemize SLResponsive · Innovative Products and Technologies · Spain

Summary of the technology

Cis-3-hexenol (mainly) and trans-4-hexenal are two molecules highly used in the cosmetic/fragances industry that are produced by chemical synthesis from non-renewable sources as petroleum. Recently, the need for this molecules obtained from renewable sources has been growing-up, but up to now the only source is the direct extraction from plants, that needs the use of high amounts of chemical solvents and thus is not an environmentally friendly and sustainable process. Anyway, the cis-3-hexanol and 4-trans-hexenal obtained by this method have a market cost much higher (from 30 - 50 USD/ Kg of synthetic molecules up to 350 - 400 USD/ Kg of natural origin/extracted molecules). Biochemize has developed a process for the renewable and sustainable production of these two molecules, through the use of recombinant microbial strains that express the genes that encode for the enzymes that are the responsible for the (metabolic bio) synthesis of both molecules in some plants that naturally produce it.
Thus, Biochemize has developed a low-cost effective process for the natural (fermentative) production of cis-3-hexenol and trans-4-hexenal, from linseed oil and through the release of linulenic acid.

Biochemize SL
Biochemize SL
Biochemize SL
Biochemize SL

Description of the technology

Biochemize has developed a process for the renewable and sustainable production of these two molecules, through the use of recombinant microbial strains that express the genes that encode for the enzymes that are the responsible for the (metabolic bio) synthesis of both molecules in some plants that naturally produce it.

Thus, Biochemize has developed a process for the natural (fermentative) production of cis-3-hexenol and trans-4-hexenal, from linseed oil and through the release of linulenic acid. The microbial strain used is E coli, and the enzymes of the pathway from linseed oil to cis-3-hexenol and 4-trans-hexenal that have beenexpressed are four. The release of the linulenic acid from linseed oil uis complete (> 99%) and then the conversion up to the final products has a yield of 85%. A complete library of microbial strains expressing one (ech) or more enzymes of the pathway is available; and it has been planned to optimize even more this process by the use of the needed enzymes directly upon the substrate (i) and/or by the use of a recombinant microbial strain that will express all the enzymes of the route.

Intellectual property status

Other forms of protection

trade secret

Current development status

Commercially available technologies

Current development status

Laboratory prototypes

Desired business relationship

Technology selling

Joint ventures

Technology development

New technology applications

Adaptation of technology to other markets

Other : Participation in the marketing/ commercial plan to produce and sale this two molecules

Technology Owner

Biochemize SL

Small and Medium Enterprise

Related keywords

  • Biological Sciences
  • Biology / Biotechnology
  • Microbiology Technology
  • Enzyme Technology
  • Agriculture and Marine Resources
  • Genetic Engineering / Molecular Biology
  • Enzymology/Protein Engineering/Fermentation
  • Industrial Products
  • Chemicals and Materials
  • Speciality/performance chemicals

About Biochemize SL

Small and Medium Enterprise from Spain

Biochemize SL is an small biotechnology R&D company (founded 8 years ago and with a team of 10 persons) located in Barcelona that is focused in the development -from basic research to scale-up and industrial production- of bioprocesses (using enzyms and/or microorganisms, wild and/or engineered for the production of APIs and all kind of high value molecules, instead of using chemical synthesis, with higher yield and lower operational cost and environmental impact. The company has its own lab facilities, and participates in public funded research projects, at european and international levels.

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