Yissum - Research Development Company of the Hebrew University

Novel Drug Delivery System of Large Molecules for Localized Sustained Release

Posted by Yissum - Research Development Company of the Hebrew UniversityResponsive · Knowhow and Research output · Israel

Summary of the technology

Novel Drug Delivery System of Large Molecules for Localized Sustained Release
Project ID : 6-2018-4643

Description of the technology

Background

The physical size of protein drugs and their susceptibility to degradation are key determinates that make them more dependent on drug delivery technologies. However formulating protein delivery systems so that they maintain their stability and remain within their efficacious and safe target doses remains a challenge.

We propose the use of a new Liposomal drug delivery system for sustained release of large biologically active molecules, in a controlled and local manner with long term biological activity. Additionally, the system would enable significantly higher drug loading in comparison to existing systems.

This novel delivery system is applicable for various applications, including: injectable cosmetics, cancer therapy and more.

In-vivo POC was demonstrated, as well as, in-vitro encapsulation and sustained release of a wide molecular range of proteins.

Project manager

Shani Bullock
VP, Business Development, Healthcare

Project researchers

Yechezkel Barenholz
HUJI, School of Medicine - IMRIC
Biochemistry and Molecular Biology

Related keywords

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  • Clinical Medicine
  • Life Science & Biotechnology
  • Drug delivery

About Yissum - Research Development Company of the Hebrew University

Technology Transfer Office from Israel

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Founded in 1964 to protect and commercialize the Hebrew University’s intellectual property. Ranked among the top technology transfer companies, Yissum has registered over 8,900 patents covering 2,500 inventions; has licensed out 800 technologies and has spun-off 90 companies. Products that are based on Hebrew University technologies and were commercialized by Yissum generate today over $2 Billion in annual sales.

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