Ouest Valorisation

Drug metabolite synthesis using electrochemistry

Posted by Christophe from Ouest ValorisationResponsive · Patents for licensing · France

Summary of the technology

We have developed an electrochemical device that can carry out oxidation reactions, stabilization, and is able to synthesize sufficient metabolites quantities from an active ingredient in solution.

Our aim is to mimic biological reactions (as oxidation) that mainly take place in liver (hepatocytes) after drug ingestion, by using electrochemistry. Thanks to a stabilization compartment, the device can continuously produce the metabolites that are naturally unstable.

Ouest Valorisation

Description of the technology

Launching any new drug onto the market requires regulatory pre-clinical studies, with a focus on identifying metabolites of the active ingredients.

When a drug is administered, active ingredient undergoes an oxidation reaction step through liver's cells, catalized by cytochrome P450 enzyme.

Current pre-clinical studies use hepatocytes, microsomes, and natural or synthetic catalysts to identify oxidized metabolites from active ingredients. These biological methods are unable to provide metabolites on large scales (some μg only), and require some heavy extra synthesis steps to get greater quantities needed for toxicity evaluation. In addition, current methods can't stabilize metabolites with a short half-life.

We have developed an electrochemical device that can carry out oxidation reactions, stabilization, and is able to synthesize sufficient metabolites quantities from an active ingredient in solution.

Our aim is to mimic biological reactions (as oxidation) that mainly take place in liver (hepatocytes) after drug ingestion, by using electrochemistry. Thanks to a stabilization compartment, the device can continuously produce the metabolites that are naturally unstable.

This electrochemical device uses single use screen-printed electrodes (PVC or cellulose) which ensure optimal performances at a low cost.

Our method also enables continuous and fast synthesis (around 100 mg/h), providing quicker results to clinicians.

In addition, the stabilization system makes it easier to analyze drugs with highly unstable metabolites.

Potential application areas

  • Pharmaceutical industry
  • Analytical laboratories

Technology advantages

  • Less costly comparted to existing methods
  • Fast to produce metabolites
  • Enables to stabilize short half-life metabolites

Intellectual property status

Granted Patent
FR1350154

Technology Owner

Ouest Valorisation

Technology Transfer Network

Additional information (attached documents)

Related keywords

  • Chemistry
  • Clinical Research, Trials
  • Medical Research
  • Medical Technology / Biomedical Engineering
  • Pharmaceutical Products / Drugs
  • Medical Furniture
  • Pharmaceutics
  • Analyses / Test Facilities and Methods
  • Chemical material testing
  • Prototypes, trials and pilot schemes
  • Other ( Clinical Medicine related )
  • Consumer related
  • Pharmaceuticals/fine chemicals
  • Medical Health related
  • Analytical and Scientific Instrumentation
  • Laboratory equipment
  • In vitro Testing, Trials Market
  • electrochemistry
  • analytical laboratories
  • oxidation
  • stabilization

About Ouest Valorisation

Technology Transfer Network from France

Ouest Valorisation is a Technology Transfer Acceleration Company.

Our mission is to add value to technological breakthroughs generated by public research laboratories in Western France area (Bretagne & Pays de la Loire), and to provide industrial partners with innovative resources.

We finance and assist technologies until they are adapted by industrial companies, taking on technological and financial risk inherent to the projects.

We enable companies to access these inventions in a quicker way to convert them into innovative products.

We play a full role in creating value.

www.ouest-valorisation.fr

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