Institut Català d'Investigació Química (ICIQ)

Photochemical metal-free method of amination of C-H bonds

Posted by Institut Català d'Investigació Química (ICIQ)Responsive · Patents for licensing · Spain

Summary of the technology

A new method for the metal-free amination of C-H bonds has been developed. The method uses readily available reagents (iodine, trilfuoromethylsuylfonamide, diacetoxyiodobenzene) and light to insert a sulfonamide moiety into a C-H bond. the method has been successfully used in the preparation of various APIs (memantine, rasagiline, sertraline). The method takes place in mild conditions and allows avoiding the use of transition metal catalysis and multiple-steps procedures. Partners are sought for the joint development of commercial applications of the method.

Description of the technology

A protocol for intermolecular C-H amination of aliphatic positions is based on the combination of a catalytic amount of iodine, visible light and sulfonamides. Under these conditions, amidyl radical are generated, which selectively address C-H bond functionalization. The reaction is of broad scope and applicable to the synthesis of pharmaceutical compounds under metal-free and mild conditions.

Current development status

Experimental technologies

Applications

API manufacture

Applications

fine chemicals preparation

Applications

flow chemistry

Desired business relationship

Patent licensing

Technology development

New technology applications

Other: Contract research for the development of a tailor-made process exploiting technology

References

https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201901673

Intellectual property status

Patent already applied for
EP19382189
Europe

Additional information (attached documents)

Related keywords

  • Agro chemicals
  • Organic Substances
  • Organic Chemistry
  • Metals and Alloys
  • Chemical Technology and Engineering
  • Chemical material testing
  • Fine Chemicals, Dyes and Inks
  • Pharmaceuticals/fine chemicals
  • Industrial Products
  • Chemicals and Materials
  • Other chemicals and materials (not elsewhere classified)
  • Other consumer services (including photo processing)
  • Speciality metals (including processes for working with metals)

About Institut Català d'Investigació Química (ICIQ)

Technology Transfer Office from Spain

ICIQ is a leading R&D institute based in Tarragona (Spain) dedicated to the development of excellent research in the fields of chemistry and catalysis.

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