Yissum - Research Development Company of the Hebrew University

Nanopatterned Surfaces for Triggered Delivery of Biologically Active Molecules

Posted by Yissum - Research Development Company of the Hebrew UniversityResponsive · Innovative Products and Technologies · Israel

Summary of the technology

Nanopatterned Surfaces for Triggered Delivery of Biologically Active Molecules
Project ID : 12-2018-5686

Description of the technology


Life Sciences and Biotechnology


delivery, drug, proteins, CRISPR, block copolymers, nanopatterning, gene therapy, gene editing

Current development stage

General list: TRL2Technology Concept Formulated


Multiple strategies exist for the targeted treatment of different cell pathologies. One ongoing challenge is the introduction of therapeutic molecules into cells. Current approaches rely on viral vectors, electroporation, or carriers. Nonetheless, many fragile cells (e.g., stem cells) do not survive the application of high voltages, and the long-term effects of viral vectors and carriers pose health concerns.

Our Innovation

  • The research team recently developed a nanopatterned block polymer surface that can release various bioactive substances with a low-voltage trigger
  • The approach offers high temporal and spatial control
  • Relevant for the growing interest in ex vivo cell therapies
  • The precursor and process requirements do not require large capital expenditures


Nanopatterned surfaces comprising alternating neutral and positively charged domains, which enables the selective assembly of polyelectrolytes over the charged domains. Some of the polyelectrolytes are electrochemically active. Various bioactive compounds can be trapped in the nano-patterned multilayer, and their release can be electrochemically triggered to generate a high local concentration in the close vicinity of the cell, driving uptake by the cell. This platform can be tailored for different bioactive molecules.


There is a large opportunity to improve current transfection means for small molecules and in the mid-term genes and proteins into cells. Such a platform is a useful research tool to effect delivery under mild conditions.

Project manager

Shani Bullock
VP, Business Development, Healthcare

Project researchers

Roy Shenhar
HUJI, Faculty of Science
The Center for Nanoscience and Nanotechnology

Meital Reches
HUJI, Faculty of Science
The Institute of Chemistry

Related keywords

  • Materials Technology
  • Chemistry
  • Medicine, Human Health
  • Biology / Biotechnology
  • Genome Research
  • Micro- and Nanotechnology related to Biological sciences
  • Recombinant DNA
  • Monoclonal Antibodies and Hybridomas
  • Gene Splicing and Manufacturing Equipment
  • Other Genetic Engineering
  • Molecular design Market
  • Microbiology Market
  • Micro- and Nanotechnology related to Biological sciences
  • Biochemistry / Biophysics Market
  • Toxicology Market
  • In vitro Testing, Trials Market
  • Stem cells and biobanks
  • Cellular and Molecular Biology Market
  • Population genetics Market
  • Gene Expression, Proteom Research Market
  • Bioinformatics Market
  • Enzymology/Protein Engineering/Fermentation
  • Genetic Engineering Market
  • Diagnostic
  • Therapeutic
  • Other Medical/Health Related
  • Agro and Marine biotech
  • Anatomy, Pathology, Immunology, Physiology
  • Clinical Medicine
  • Chemicals and Materials
  • Life Science & Biotechnology
  • Drug delivery

About Yissum - Research Development Company of the Hebrew University

Technology Transfer Office from Israel

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Founded in 1964 to protect and commercialize the Hebrew University’s intellectual property. Ranked among the top technology transfer companies, Yissum has registered over 8,900 patents covering 2,500 inventions; has licensed out 800 technologies and has spun-off 90 companies. Products that are based on Hebrew University technologies and were commercialized by Yissum generate today over $2 Billion in annual sales.

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