Efficient and selective magnetic adsorbent for removal of purine compounds and nucleic acids from liquid matrices

Posted by UACOOPERA from uacooperaResponsive · Patents for licensing · Portugal

Summary of the technology

New low cost magnetic adsorbents prepared from egg-shell membranes and deep eutectic solvents, which selectively and effectively remove purine compounds and nucleic acids from liquid matrices, such as fermented drinks and/or alcoholic beverages.

UATEC - Unidade de Transferência de Tecnologia
UATEC - Unidade de Transferência de Tecnologia


Most alcoholic drinks, such as wine and beer, are prepared by fermentation. In addition to ethanol, beverages have several compounds in their composition, such as nucleic acids and their degradation products (purine-based compounds). Purine compounds when ingested by humans are broken into uric acid, responsible for several diseases, including gout and increased abdominal perimeter.

To reduce the purine compounds content in fermented beverages, enzymatic degradation processes have been proposed. However, this approach has a reduced degradation rate and a high cost. The adsorption/removal of purine-based compounds using activated carbon and zeolites has also been described; however, these processes have low selectivity (since amino acids, aromas and/or other essential nutrients are also removed), thus limiting their application.

The present technology comprises the use of magnetic adsorbents capable of selectively and efficiently remove purine compounds and nucleic acids from liquid matrices. The adsorbent materials are sustainable and of low cost since they are prepared using a residue, the eggshell membrane, and deep eutectic solvents derived from natural sources.


This technology can be used for purine compounds removal from:

ALCOHOLIC AND FERMENTED BEVERAGES (food and beverages industry)

BIOLOGICAL MATRICES (R&D and biopharmaceutical and biotechnology industries)



EFFICIENCY: 80-90% removal efficiency of purine compounds from laboratorial samples.

LOW COST AND SUSTAINABILITY: produced from eggshell membranes and deep eutectic solvents derived from natural sources.


Provisional patent application filed in Portugal (priority date: 29-10-2018).


TRL 4: small-scale laboratory prototype. Ongoing studies with several types/samples of beer.

With the necessary support, 6 months are sufficient for the respective scale-up and commercialization.

The experimental protocol for the attainment and production of the technology is implemented at the laboratorial level, and inventors are available to publicly exhibit the technology.


Magnetic adsorbent

Purine compounds

Fermented beverages

Eggshell membrane

Nucleic acids

Deep eutectic solvent


Researchers from Aveiro Institute of Materials (CICECO) from the University of Aveiro.


Licensing agreement.


The University of Aveiro seeks industrial partners within food/beverages and biotechnology areas with interest on the application and/or commercialization of magnetic adsorbent materials for purine compounds and nucleic acids removal from liquid matrices.

Technology #CI18013

Intellectual property status

Patent already applied for

Technology Owner


Technology Transfer Office

UACOOPERA University of Aveiro

Technology Transfer Office at uacoopera

Additional information (attached documents)

Related keywords

  • Industrial manufacturing, Material and Transport Technologies
  • Materials Technology
  • Physical Sciences and Exact Sciences
  • Chemistry
  • Organic Chemistry
  • Separation Technologies
  • Filtration and Membrane Processes
  • Adsorption
  • Biological Sciences
  • Medicine, Human Health
  • Physiology
  • Biology / Biotechnology
  • Micro- and Nanotechnology related to Biological sciences
  • Industrial Biotechnology
  • Agrofood Industry
  • Technologies for the food industry
  • Drink Technology
  • Food Additives/Ingredients/Functional Food
  • Food Processing
  • Food Technology
  • Protecting Man and Environment
  • Waste Management
  • Biotreatment / Compost / Bioconversion
  • Recycling, Recovery
  • Consumer related
  • Food and Beverages
  • Wine and liquors
  • Health food
  • Industrial Products
  • Chemicals and Materials
  • Membranes and membrane-based products
  • Other speciality materials
  • Speciality/performance chemicals
  • Pollution and Recycling Related
  • Chemical and solid material recycling

About uacoopera

Technology Transfer Office from Portugal

The University of Aveiro is a young and innovative university, which fosters entrepreneurship and technology and knowledge transfer, with expertise in a wide range of knowledge areas namely IT, Life Sciences (Biology, Chemistry, Biochemistry, Health, Environmental Sciences), Nanotechnology and Materials Science, Mechanics, Physics, Mathematics, Building, Design and Management. uacoopera is the Technology Transfer Office of University of Aveiro. This office engages in value adding activities such as start-up and spin-off creation, support to university-industry cooperation (sponsored research and consultancy services), IP protection and prosecution, licensing, marketing, among others. It covers four main interrelated functional areas – Intellectual Property Management, Licensing, Entrepreneurship, and Industry Liaison.

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