Yissum - Research Development Company of the Hebrew University

Mycobacterium marinum bacteria-based vaccine for fish

Posted by Yissum - Research Development Company of the Hebrew UniversityResponsive · Innovative Products and Technologies · Israel

Summary of the technology

Mutant Mycobacterium marinum bacteria as a vaccine against Mycobacteriosis in fish

Project ID : 24-2018-4681

Yissum - Research Development Company of the Hebrew University

Description of the technology


Veterinary & Animal Sciences


Vaccine fish mycobacterium,

fish mycobacteriosis,

Mycobacterium marinum

Current development stage

General list: TRL3 Experimental proof of concept


  • M. marinum is a major causative agent of fish Mycobacteriosis, a common bacterial disease in many species of freshwater, brackish water and salt water fish - specifically harming food fish such as Sea Bass, H. S. Bass and Sea Bream, reared under intensive conditions.
  • M. marinum bacteria has several isolates, some are potentially zoonotic specifically harmful for marine and aquarium workers.
  • M. marinum bacteria harms zebrafish- a commonly used research model, and is considered a major problem in research facilities.
  • Today there is no effective vaccine against M. marinum bacteria. In addition, there are no prescribed medications against this bacteria.

Our Innovation

A new Mycobacterium marinum (M. marinum ) bacteria-based vaccine can be used as aneffective vaccine against the Mycobacteriosis disease in fish.


  • Worldwide problem with a large market.
  • M. marinum bacteria harms zebrafish, and is considered a major problem in research facilities.
  • Sea Bass is one of thefood fishharmed by M. marinum. In Israel for example, the high incidence of M. marinum, caused the fish growers to stop growing this species

Project manager

Ilya Pittel

Project researchers

Daniel Barkan
HUJI, Faculty of Agricultural, Food and Environmental Quality Sciences
The Koret School of Veterinary Medicine

Related keywords

  • Veterinary Medicine
  • Agriculture and Marine Resources
  • Resources of the Sea, Fisheries
  • Fish / Fisheries / Fishing Technology
  • Marine Science
  • Animal health
  • Veterinary & Animal Sciences
  • Drugs & Vaccines

About Yissum - Research Development Company of the Hebrew University

Technology Transfer Office from Israel

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Founded in 1964 to protect and commercialize the Hebrew University’s intellectual property. Ranked among the top technology transfer companies, Yissum has registered over 8,900 patents covering 2,500 inventions; has licensed out 800 technologies and has spun-off 90 companies. Products that are based on Hebrew University technologies and were commercialized by Yissum generate today over $2 Billion in annual sales.

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