Summary of the technology
a novel synthetic peptide, for the inhibition of bacterial cell-cell communications (quorum sensing, QS), in order to inhibit virulent gene expression. Specifically, for Bacillus cereus bacteria
Project ID : 23-2018-4670
Description of the technology
Food & Nutrition
Bacillus cereus bacteria,
Quorum sensing inhibitors,
Bacterial cell –cell communication,
Antibiofilm, Antispores. Food poisoning
Current development stage
General list: TRL4 Technology validated in lab
- Antimicrobial resistance is one of the main threats of our era to human health. A rising number drug resistant cases across the world is creating a need to develop new antibiotics to fight against infectious diseases.
- B. cereus is a well-known foodborne pathogen. Since it produces spores, this bacteria is considered to be a challenge in the food industry, specifically in pastry, shrimp, pasta, potato purer, souses, rice, cereals, and baby formulas. B. Cereus is responsible for foodborne illnesses, watery diarrhea, abdominal cramps, nausea and vomiting. In rare cases, B. cereus toxins are fatal for infants.
We have invented a novel synthetic peptide, to inhibit bacterial cell-cell communications (quorum sensing), in order to inhibit virulent gene expression. Specifically, this is intended for Bacillus cereus bacteria, as a proof of concept for activity in gram plus bacteria.
A main advantage of the proposed technology is that the inhibition of the bacteria is caused by QS cell-cell communication interference, without effecting bacterial growth and without fighting the bacteria itself.Thus survival stress, which is caused by antibiotics is prevented, and therefore the chances for bacterial resistance is low.
- The peptides are effective against biofilms and spores formation
- The synthetic peptide is very short (7aa)
- selective for a specific bacteria
- The synthetic peptide can be used as a food additive to prevent spore formation (see specific food list above) or as a coating agent to prevent biofilm formation.
- The current research is focused on B. cereus and can be expanded to include additional gram positive bacteria
- The synthetic peptide can be used against B. thuringiensis (from the same family) as biological pesticides against insects