Yissum - Research Development Company of the Hebrew University

A Novel Synthetic Peptide to Inhibit Biofilm Creation of Bacillus cereus bacteria

Posted by Yissum - Research Development Company of the Hebrew UniversityResponsive · Innovative Products and Technologies · Israel

Summary of the technology

a novel synthetic peptide, for the inhibition of bacterial cell-cell communications (quorum sensing, QS), in order to inhibit virulent gene expression. Specifically, for Bacillus cereus bacteria
Project ID : 23-2018-4670

Description of the technology


Food & Nutrition


antimicrobial peptide,

antiviolence peptide,

Bacillus cereus bacteria,

Quorum sensing inhibitors,

Bacterial cell –cell communication,

Antibiofilm, Antispores. Food poisoning

Current development stage

General list: TRL4 Technology validated in lab


  • Antimicrobial resistance is one of the main threats of our era to human health. A rising number drug resistant cases across the world is creating a need to develop new antibiotics to fight against infectious diseases.
  • B. cereus is a well-known foodborne pathogen. Since it produces spores, this bacteria is considered to be a challenge in the food industry, specifically in pastry, shrimp, pasta, potato purer, souses, rice, cereals, and baby formulas. B. Cereus is responsible for foodborne illnesses, watery diarrhea, abdominal cramps, nausea and vomiting. In rare cases, B. cereus toxins are fatal for infants.

Our Innovation

We have invented a novel synthetic peptide, to inhibit bacterial cell-cell communications (quorum sensing), in order to inhibit virulent gene expression. Specifically, this is intended for Bacillus cereus bacteria, as a proof of concept for activity in gram plus bacteria.

A main advantage of the proposed technology is that the inhibition of the bacteria is caused by QS cell-cell communication interference, without effecting bacterial growth and without fighting the bacteria itself.Thus survival stress, which is caused by antibiotics is prevented, and therefore the chances for bacterial resistance is low.

  • The peptides are effective against biofilms and spores formation
  • The synthetic peptide is very short (7aa)
  • selective for a specific bacteria


  • The synthetic peptide can be used as a food additive to prevent spore formation (see specific food list above) or as a coating agent to prevent biofilm formation.
  • The current research is focused on B. cereus and can be expanded to include additional gram positive bacteria
  • The synthetic peptide can be used against B. thuringiensis (from the same family) as biological pesticides against insects

Project manager

Amichai Baron
VP, Head of Business Development, Agritech & Envir

Project researchers

Zvi Hayouka
HUJI, Faculty of Agricultural, Food and Environmental Quality Sciences
Biochemistry, Food Science and Nutrition

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  • Peptide / Protein

About Yissum - Research Development Company of the Hebrew University

Technology Transfer Office from Israel

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Founded in 1964 to protect and commercialize the Hebrew University’s intellectual property. Ranked among the top technology transfer companies, Yissum has registered over 8,900 patents covering 2,500 inventions; has licensed out 800 technologies and has spun-off 90 companies. Products that are based on Hebrew University technologies and were commercialized by Yissum generate today over $2 Billion in annual sales.

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