Yissum - Research Development Company of the Hebrew University

Novel Methods for Preparing Polymeric or Hybrid Microcapsules Using Oil-in-Oil Emulsions

Posted by Yissum - Research Development Company of the Hebrew UniversityResponsive · Innovative Products and Technologies · Israel

Summary of the technology

Novel Methods for Preparing Polymeric or Hybrid Microcapsules Using Oil-in-Oil Emulsions
Project ID : 31-2016-4313

Description of the technology


Encapsulation, oil-in-oil emulsions, polymeric

Current development stage

TRL4 Technology validated in lab


  • Microencapsulation is defined as a process of confining micron-sized particles or droplets in a polymeric shell called microsphere/microcapsule, having an average diameter ranging from 100 nm to several hundred micrometers.
  • Interfacial polymerization (IFP) has been intensively used in the microencapsulation process due to its high yield, moderate and fast synthesis.
  • IFP reactions take place at the boundary of two phases while each phase contains different monomer to form the shells of microcapsules. Up to date, these microcapsules are prepared using either oil-in-water or water-in-oil emulsions.

Our Innovation

A new method for preparing polymeric or hybrid microcapsules using oil-in-oil emulsions, enabling the encapsulation of various hydrophilic and hydrophobic materials.

  • Enables to encapsulate water-sensitive materials.
  • Enables to encapsulate air-sensitive materials.
  • Enables to develop new formulations.


The developed method is based on oil-in-oil emulsification and IFP.

The method enables for the first-time encapsulation purely of hydrophilic materials such as polyethylene glycol (PEG), glycerol, ethylene glycol within polymeric microspheres such as polyurea.

Polymeric microcapsules dispersed in polar oils such as PEG were demonstrated. These capsules contained in their core non-polar materials such as toluene, xylene, heptane.

This method enables the formation of microcapsule as opposed to regular monomers, used widely in the preparation of polyurea capsules, that lead to the formation of bulk polymers.

Furthermore, a method for preparing microcapsules with hybrid shells was developed. These shells are composed of polymer and inorganic materials like silica.


  • Pharmaceutical industry
  • Agricultural industry
  • Cosmetic industry
  • Biotechnology industry

Project manager

Matt Zarek

Project researchers

Raed Abu-Reziq
HUJI, Faculty of Science
The Institute of Chemistry

Related keywords

  • Materials Technology
  • Chemistry
  • Agrofood Industry
  • Agriculture and Marine Resources
  • Food Technology
  • Care, Hygiene, Beauty, Cosmetics
  • Biology / Biotechnology
  • Chemicals and Materials
  • Chemistry & Materials
  • formulations

About Yissum - Research Development Company of the Hebrew University

Technology Transfer Office from Israel

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Founded in 1964 to protect and commercialize the Hebrew University’s intellectual property. Ranked among the top technology transfer companies, Yissum has registered over 8,900 patents covering 2,500 inventions; has licensed out 800 technologies and has spun-off 90 companies. Products that are based on Hebrew University technologies and were commercialized by Yissum generate today over $2 Billion in annual sales.

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