Yissum - Research Development Company of the Hebrew University

Novel Methods for Micro-Encapsulation by Non-Aqueous Sol-Gel Routes

Posted by Yissum - Research Development Company of the Hebrew UniversityResponsive · Innovative Products and Technologies · Israel

Summary of the technology

Novel microencapsulation technology based on oil-in-oil emulsification and non-aqueous sol-gel chemistry
Project ID : 31-2016-4312

Description of the technology


Chemistry & Materials


Emulsification, Encapsulation, water-sensitive or air-sensitive components

Current development stage

TRL4 Technology validated in lab


  • The main method employed today for the synthesis of silica microcapsules is based on an emulsion/sol-gel approach. This approach has been applied successfully in the microencapsulation of hydrophobic materials.
  • The encapsulation of hydrolytically unstable ingredients cannot be achieved by the current microencapsulation methods as they rely on water-based emulsions.
  • There are many candidates of pharmaceutical, agricultural or cosmetic active components that are water-sensitive or air-sensitive. To enable their encapsulation in silica shells, non-aqueous sol-gel routes must be involved.

Our Innovation

The researchers developed a novel microencapsulation technology. The technology is based on oil-in-oil emulsification and non-aqueous sol-gel chemistry that enables the encapsulation of various hydrophilic and hydrophobic active materials. The technology make it possible to encapsulate water-sensitive or air-sensitive actives that previously couldn't be encapsulated by any other microencapsulation methods.

  • Encapsulate very hydrophilic materials purely without the need to dilute them in water.
  • Overcome the stability limitation of water-sensitive actives.
  • Applied for other types of hydrophilic or hydrophobic active materials.
  • Can be used to prepare microcapsules that are composed of different types of metal oxide.


  • Silica microcapsules containing pure polyethylene glycol (PEG) or glycerol in their core was successfully demonstrated for the first time.
  • Different types of ionic liquids, deep eutectic solvents, highly water-soluble agricultural actives were also microencapsulated as well as Vitamin A and Cymoxanil.
  • Octyl Methoxy Cinnamate (OMC) was encapsulated by a method in which the hydrophobic OMC is emulsified in PEG and then a silica shell is formed around the OMC droplets.
  • Taxol, anti-cancer drug, was microencapsulated in a similar way.

Figure 1. Scanning electron microscopy (SEM) images of silica microcapsules containing PEG in their cores.


  • Pharmaceutical industry
  • Agricultural industry
  • Cosmetic industry
  • Chemical industry
  • Biotechnology industry

Project manager

Matt Zarek

Project researchers

Raed Abu-Reziq
HUJI, Faculty of Science
The Institute of Chemistry

Related keywords

  • Materials Technology
  • Chemistry
  • Agriculture and Marine Resources
  • Agrofood Industry
  • Care, Hygiene, Beauty, Cosmetics
  • Chemicals and Materials
  • Chemistry & Materials
  • formulations

About Yissum - Research Development Company of the Hebrew University

Technology Transfer Office from Israel

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Founded in 1964 to protect and commercialize the Hebrew University’s intellectual property. Ranked among the top technology transfer companies, Yissum has registered over 8,900 patents covering 2,500 inventions; has licensed out 800 technologies and has spun-off 90 companies. Products that are based on Hebrew University technologies and were commercialized by Yissum generate today over $2 Billion in annual sales.

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