Yissum - Research Development Company of the Hebrew University

VEGF Stimulation for Anti-Aging Treatment

Posted by Yissum - Research Development Company of the Hebrew UniversityResponsive · Innovative Products and Technologies · Israel

Summary of the technology

A treatment resulting in attenuation of multiple aging phenotypes ("healthy aging") and lifespan extension
Project ID : 6-2018-4548

Description of the technology


Anti-Aging, Vascular Endothelial Growth Factor

Current development stage

TRL3 - hypothesis testing and intial POC demonstrated in limited number of in-vitro models


With continuous increase in the elderly population, many age-related health problems have become a major healthcare issue.

Attenuating deleterious age-related processes taking place in multiple organs is highly desirable.

Our Innovation

A novel method for attenuating and/or delaying age-related deterioration using an externally supplied molecule that stimulates one of the body's own physiological signal transduction pathways at a very low level.

  • Beneficial effect on multiple organs
  • Attenuate and/or delay development of adverse phenotypes that develop naturally in aging individuals

Pre-clinical Results

  • Initial analysis of well-known age-related processes taking place in multiple organs reveals a remarkable attenuation of these processes in mice. The natural signal transduction pathway has been stimulated at low level with no side-effects.
  • The finding uncovers a compelling evidence for the beneficial effect of this treatment per the processes like: Attenuation of bone mass loss, decreasing subcutaneous fat loss, decreasing development of a fatty liver and pancreas (steatosis) and counteracting age-related hematopoietic imbalances.
  • The native induction resulted in dramatic extension of the individuals' lifespan


  • Slow aging
  • Lifeextension
  • Effective treatment for age-related symptoms or disorders such as osteoporosis, steatosis, hematopoietic disturbances, sarcopenia, etc.

Project manager

Mel Larrosa
VP Business Development Healthcare

Project researchers

Eli Keshet
HUJI, School of Medicine - IMRIC
Developmental Biology and Cancer Research

Related keywords

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About Yissum - Research Development Company of the Hebrew University

Technology Transfer Office from Israel

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Founded in 1964 to protect and commercialize the Hebrew University’s intellectual property. Ranked among the top technology transfer companies, Yissum has registered over 8,900 patents covering 2,500 inventions; has licensed out 800 technologies and has spun-off 90 companies. Products that are based on Hebrew University technologies and were commercialized by Yissum generate today over $2 Billion in annual sales.

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