Yissum - Research Development Company of the Hebrew University

New Octameric High Affinity Biotin Binding Templates

Posted by Yissum - Research Development Company of the Hebrew UniversityResponsive · Innovative Products and Technologies · Israel

Summary of the technology

Cluster9
protein sequence from Hoefleo Phototropica has an extremely high affinity towards biotin. Fragment of this protein was identified to have the sufficient feature of the biotin binding properties.
Project ID : 6-2017-4514

Description of the technology

Our Innovation

A unique protein sequence from Hoefleo Phototropica with extremely high affinity towards biotin. The fragment of this protein was identified to have the sufficient feature of the biotin binding properties.

Advantages

  • Increased affinity of binding to biotin
  • Increased stability of the biotin conjugate over avidin-biotin
  • Increased signal amplification over avidin-biotin

Opportunity

The improved properties of octameric-hoefavidin-biotin might be exploited as an improvementover streptavidin, for applications including ELISA, Blotting, Immunology, Peptide & proteinpurification, DNA labeling & purification, Electron microscopy, Crosslinking, Affinity targeting, Light& fluorescent microscopy, Localization, Drug delivery, Pathology, Affinity therapy, Cell separation,Phage and yeast display technologies, Flow cytometry, Bio-sensing, and Nanoparticle probes.

Project manager

Mel Larrosa
VP Business Development Healthcare

Project researchers

Oded Livnah
HUJI, Faculty of Science
The Alexander Silberman Institute for Life Sciences

Related keywords

  • Clean Industrial Technologies
  • Other (uncategorised)
  • Life Science & Biotechnology
  • Research / Development tools

About Yissum - Research Development Company of the Hebrew University

Technology Transfer Office from Israel

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Founded in 1964 to protect and commercialize the Hebrew University’s intellectual property. Ranked among the top technology transfer companies, Yissum has registered over 8,900 patents covering 2,500 inventions; has licensed out 800 technologies and has spun-off 90 companies. Products that are based on Hebrew University technologies and were commercialized by Yissum generate today over $2 Billion in annual sales.

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