Targeted Drug Delivery by Cathepsin Nanofiber Substrates
Cluster8 Cluster9 Cathepsin Nanofiber Substrates as Potential Agent for Targeted Drug Delivery Project ID : 6-2017-4395
Summary of the technology
Cathepsin Nanofiber Substrates as Potential Agent for Targeted Drug Delivery
Project ID : 6-2017-4395
Description of the technology
Life Sciences and Biotechnology
Carriers, Cathepsin proteases, Tetra-peptides
Current development stage
TRL4 - POC & Safety of candidate drug formulation is demonstrated in defined animal model
A novel approach for developing self-assembled tetra-peptides serving as substrates of the cathepsin proteases.
Fig. 1: Drug release profile. Dox was precipitated by ammoniumsulfate to generate Dox particles (DPs), TPS4 was added and allowed to assemble overnight. Bright field (a) and fluorescentmicroscopy of DP-TPS4 (b). Analysis of DPs alone forming unstructured aggregates as well as fibers (white arrow), SEM(c) and TEM(d). Analysis ofDPs-TPS4 showing defined nanofibers by SEM(e) and TEM(f). Release profile of Dox fromDP-TPS4 nanostructure in the presence and absence of cathepsin B (g). After 8 h 91.8±0.3% of total drug was released from DP-TPS4 following cathepsin B treatment. Results are described with standard error, ** p b 0.01, *** p b 0.001, **** p b 0.0001.