Programable Release of 3D-Printed Drugs
Cluster9 Project ID : 6-2017-4487
Summary of the technology
Project ID : 6-2017-4487
Description of the technology
A novel approach for fabrication of a programmable oral dosage system in the form of responsive hydrogels, that can be swollen and then release a drug at specific conditions such as pH, by 3D Digital Light Processing (DLP) printing technology.
Oral dosage forms of pH responsive hydrogels were 3D printed using monomer (acrylic acid), cross-linker (PEGDA) and Photo-initiator (TPO nanoparticles) that lead to biocompatible polymers.
The currently developed programmable pharmaceutical oral formulations enable tight control over the dose, composition and bioavailability, than achieved by conventional dosage forms.
Hydrogels are three-dimensional cross-linked network of hydrophilic polymers which can be used for drug delivery systems for controlled drug release. For example using responsive hydrogels, it is possible to control the volume of the dosage form after uptake and to minimize drug release in the stomach while enhancing its release in the intestinal pH.
The technology is based on photo-polymerization, enabled by DLP for curing photo-reactive compositions. The localized polymerization is performed within a bath filled with a polymerizable ink, usually by proper focusing UV light. DLP allows high resolution, complex structures, low printing cost and large build size.
The printed structures exhibited pH responsiveness and structure dependence of swelling and release.
Fig. 1:Images of the 3D printed hydrogel tablets using DLP technique. (A. Box; B. Hemisphere; C. 5X5; D. Hive). E-F are scanning electron microscopy images of D and C shapes respectively. Photo: 3D Print. Med. 219–229, 2017)
Fig.2: Left: Images of Sulforhodamine B loaded 3D printed tablets with different shapes, before and after 24h swelling in phosphate buffer (pH 7.4); A. Box; B. Hemisphere; C. 5X5; D. Hive.
Right: Correlation between the tablet expansion and drug release in different 3D printed shape. Measurement were taken at 0,1,2,4,8 and 24 hours. Photo: 3D Print. Med. 219–229, 2017
Personalized and programmable medicine applications using oral delivery such as: