Yissum - Research Development Company of the Hebrew University

Differential Production of Cannabinoids CBD and THC

Posted by Yissum - Research Development Company of the Hebrew UniversityResponsive · Innovative Products and Technologies · Israel

Summary of the technology

Haim Rabinowitch – Differential Production Of Cannabinoids CBD and THC. Prof. Rabinowitch is a world renown expert breeder of tomatoes (the long shelf life trait of cherry tomato currently found in the market were bred by Prof. Rabinowitch). Additionally, Prof. Rabinowitch breeds garlic and potatoes and is currently looking for sponsored research funding to breed Cannabis for a desired THC/CBD ratio. http://www.yissum.co.il/technologies/project/4417
Project ID : 8-2017-4417

Description of the technology


The most common type of cannabinoids is tetrahydrocannabinol (THC) which ensures a psychedelic high but also helps in relieving chronic pain and stimulates poor appetite. On the other hand, cannabidiol (CBD) as well as CBG and CBC are able to reduce the THC action and provide anti-seizure and anti-inflammation effects. The large number of potent chemicals in this plant and their interaction still have to be better classified and studied.

One thing in common, is that only non-pollinated female flowers are of value. Hence, development of female strains, either by genetic control or chemical/physiological means becomes a great advantage.

Currently, most, if not all, Cannabis plantation are clonally propagated with the consequent risks of pathogenic contamination and up to complete loss of the crop. Nuclear stock has to be raised under protected conditions – a costly and risky challenge.

Research Outlook

Creating new medical cannabis strains, breeders focus on the content of THC and CBD, thus strains with high level of THC or CBD are available on the market. However, there are also other types of cannabinoids that are full of beneficial effects. Selection for desired traits can result in plants yielding high quantities and better expression of CBD and THC groups of compounds, to achieve desired medical outcome.

Production of seed propagated female hybrid populations, rich in the desired cannabinoids may further enhance production and therefore reduce risks and costs.


  • Higher yields of female only plants
  • Larger quantities of THC can be produced for extraction
  • Higher levels of THC produced per plant
  • Reduced contamination

Project manager

Ilya Pittel

Project researchers

Haim Rabinowitch
HUJI, Faculty of Agricultural, Food and Environmental Quality Sciences

Related keywords

  • Agro chemicals
  • Agriculture
  • Agricultural genetic engineering applications
  • Agricultural chemicals
  • Agriculture, Forestry, Fishing, Animal Husbandry and Related Products
  • agriculture
  • plant genetics

About Yissum - Research Development Company of the Hebrew University

Technology Transfer Office from Israel

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Founded in 1964 to protect and commercialize the Hebrew University’s intellectual property. Ranked among the top technology transfer companies, Yissum has registered over 8,900 patents covering 2,500 inventions; has licensed out 800 technologies and has spun-off 90 companies. Products that are based on Hebrew University technologies and were commercialized by Yissum generate today over $2 Billion in annual sales.

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