Yissum - Research Development Company of the Hebrew University


Posted by Yissum - Research Development Company of the Hebrew UniversityResponsive · Innovative Products and Technologies · Israel

Summary of the technology

Self-assembly of fluorine-capped moieties for prevention of biofilms
Keywords: self-assembly, dental, dentistry, biolfilm, disruption
Project ID : 9-2015-3142

Yissum - Research Development Company of the Hebrew University

Description of the technology

Reches Meital, HUJI, Faculty of Science, The Institute of Chemistry


The surface chemistry and topography of implants are very important to their design. This is because the interface between the implant and the human body will determine how well the implant would integrate in the desired tissue.Surface roughness encourages mammalian cells adhesion and therefore implant integration, however, this roughness also attracts bacteria and therefore assisst bacterial colonization. This colonization leads to the formation of a well-defined bacterial networktermed “Biofilm”.

Biofilm formation on medical devices and implants leads to severe infection which may result in implant failure and even in patient death.Therefore, there is a need for a coating that will resist bacterial attachment and encourage cell adhesion.

Our Innovation

This invention is a simple molecule, a peptide that consistsofonly 6 amino acids. It contains an element thatresists bacterial adhesion,a motif that encourages mammalian adsorption and amino acids that encore the peptide to the surface and mediate its self-assembly into a coating.


We developed, manufactures and sells a novel coating which prevents bacterial adhesion to surfaces. The coating spontaneously formed by the self-assembly of a tripeptide. The advantages of using peptides for this purpose are concealed in peptides' biocompatibility, chemical diversity, and ease for large scale synthesis. The coating is formed by the peptide on various surfaces (glass, titanium, silicon oxide, metals and polymers). The coating completely prevents the first step of fouling which involves the adsorption of bioorganic molecules to the substrate.


·A simple molecule made of amino acids.

·The molecule spontaneously forms a coating under mild conditions (either room or body temperature) without any curing step.

·An agent capable of preventing or arresting adsorption of organic and/or bio-organic materials to a surface.

·An element that encourages attachment of cells to the surface.


The materials of the invention are capable of attracting cells from multicellular organisms and preventing antifouling by unicellular organisms. The materials of the invention can be used in biotechnological processes with any eukaryotic cells including mammalian cells or plant cells.


The invention provides a method for preventing bacterial contamination while theimplant is integratedinto the human body. The invention provides a method for prolonging the lifetime of an implant and for stimulating or encouraging bone healing or absorption of an implant after implantation.

Project manager

Matt Zarek

Project researchers

Meital Reches
HUJI, Faculty of Science
The Institute of Chemistry

Related keywords

  • Materials Technology
  • Medicine, Human Health
  • Biology / Biotechnology
  • Genome Research
  • Micro- and Nanotechnology related to Biological sciences
  • Recombinant DNA
  • Monoclonal Antibodies and Hybridomas
  • Gene Splicing and Manufacturing Equipment
  • Other Genetic Engineering
  • Molecular design Market
  • Microbiology Market
  • Micro- and Nanotechnology related to Biological sciences
  • Biochemistry / Biophysics Market
  • Cellular and Molecular Biology Market
  • Population genetics Market
  • Bioinformatics Market
  • Enzymology/Protein Engineering/Fermentation
  • Genetic Engineering Market
  • Diagnostic
  • Therapeutic
  • Anatomy, Pathology, Immunology, Physiology
  • Clinical Medicine
  • Chemicals and Materials
  • Life Science & Biotechnology
  • medical device

About Yissum - Research Development Company of the Hebrew University

Technology Transfer Office from Israel

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Founded in 1964 to protect and commercialize the Hebrew University’s intellectual property. Ranked among the top technology transfer companies, Yissum has registered over 8,900 patents covering 2,500 inventions; has licensed out 800 technologies and has spun-off 90 companies. Products that are based on Hebrew University technologies and were commercialized by Yissum generate today over $2 Billion in annual sales.

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